ReviewFrontiers in neurology2018
Hypocretin as a Hub for Arousal and Motivation.
Review in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Trial
- Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling.Cell discovery · 2026Article
- Sleep deprivation engages the orexin/hypocretin system to regulate food reward seeking.The international journal of neuropsychopharmacology · 2025Article
- Emerging medications and pharmacological treatment approaches for substance use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior.Current topics in behavioral neurosciences · 2025Review
- Effects of Traumatic Brain Injury on the Orexin/Hypocretin System.Neurotrauma reports · 2025Review
- Machine learning models to predict ligand binding affinity for the orexin 1 receptor.Artificial intelligence chemistry · 2024Article
- Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice.Journal of neurotrauma · 2023Article
- Peripheral vs. core body temperature as hypocretin/orexin neurons degenerate: Exercise mitigates increased heat loss.Peptides · 2023Article
- Rewarding-unrewarding prediction signals under a bivalent context in the primate lateral hypothalamus.Scientific reports · 2023Article
- Neural bases of freedom and responsibility.Frontiers in neural circuits · 2023Review
- The Arousal-motor Hypothesis of Dopamine Function: Evidence that Dopamine Facilitates Reward Seeking in Part by Maintaining Arousal.Neuroscience · 2022Article
- From Molecule to Behavior: Hypocretin/orexin Revisited From a Sex-dependent Perspective.Endocrine reviews · 2022Review
- Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.Biological psychiatry · 2022Article
- Hypothalamic deep brain stimulation as a strategy to manage anxiety disorders.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Orexin/Hypocretin System Dysfunction in ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations).Neuropsychiatric disease and treatment · 2022Article
- Oxytocin in Huntington's disease and the spectrum of amyotrophic lateral sclerosis-frontotemporal dementia.Frontiers in molecular neuroscience · 2022Review
- Melanin-concentrating hormone promotes anxiety and intestinal dysfunctionFrontiers in pharmacology · 2022Article
- The Orexin receptors: Structural and anti-tumoral properties.Frontiers in endocrinology · 2022Review
- Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to integrate and regulate sleep, feeding, stress, energy balance, reward, and motivated behavior. Within these populations, the hypocretin/orexin neurons are among the most well studied. Here, we provide an overview on how these neurons act as a central hub integrating sensory and physiological information to tune arousal and motivated behavior accordingly. We give special attention to their role in sleep-wake states and conditions of hyper-arousal, as is the case with stress-induced anxiety. We further discuss their roles in feeding, drug-seeking, and sexual behavior, which are all dependent on the motivational state of the animal. We further emphasize the application of powerful techniques, such as optogenetics, chemogenetics, and fiber photometry, to delineate the role these neurons play in lateral hypothalamic functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.