ReviewFrontiers in behavioral neuroscience2018
Abnormal Serotonin Levels During Perinatal Development Lead to Behavioral Deficits in Adulthood.
Review in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Maternal excessive gestational weight gain as a risk factor for autism spectrum disorder in offspring: a systematic review.BMC pregnancy and childbirth · 2020Pooled it
- Neurodevelopmental effects of early life stress: PFC and cognition.Neuroscience and biobehavioral reviews · 2026Review
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- Divergent representation and processing of task cues in sensory and prefrontal cortices of preterm-born mice.Nature communications · 2026Article
- Controversial effects of metformin on human physiology and pathophysiology.Frontiers in pharmacology · 2026Review
- The sertraline metabolite, desmethylsertraline, may be implicated in adverse outcomes reported after gestational sertraline use: insights from a study in zebrafish.Pharmacological reports : PR · 2025Article
- Arsenic and vanadium co-exposure induced cerebellar neurotoxicity: aggravates apoptosis, inflammation, oxidative stress, and locomotor deficits in juvenile BALB/c mice.Anatomy & cell biology · 2025Article
- Phytochemicals Modulate Biosynthesis and Function of Serotonin, Dopamine, and Norepinephrine for Treatment of Monoamine Neurotransmission-Related Psychiatric Diseases.International journal of molecular sciences · 2025Review
- Investigating the association between metabolic syndrome conditions and perinatal mental illness: a national administrative claims study.BMC pregnancy and childbirth · 2024Observational
- Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex.Nature communications · 2024Article
- Brain serotonin and serotonin transporter expression in male and female postnatal rat offspring in response to perturbed early life dietary exposures.Frontiers in neuroscience · 2024Article
- Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain.Metabolites · 2023Article
- Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum.Frontiers in public health · 2023Article
- Positive Effects of α-Lactalbumin in the Management of Symptoms of Polycystic Ovary Syndrome.Nutrients · 2022Review
- Acute Prenatal Hypoxia in Rats Affects Physiology and Brain Metabolism in the Offspring, Dependent on Sex and Gestational Age.International journal of molecular sciences · 2022Article
- Association between platelet MAO activity and lifetime drug use in a longitudinal birth cohort study.Psychopharmacology · 2022Article
- Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats.International journal of tryptophan research : IJTR · 2022Article
- Neonatal Reserpine Administration Produces Widespread Neuronal Losses and ⍺-Synuclein Inclusions in a Rat Model.Neurotoxicity research · 2021Article
- Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission.Molecular psychiatry · 2021Article
- Serotonergic regulation of the dopaminergic system: Implications for reward-related functions.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Serotonin (5-HT) is one of the best-studied modulatory neurotransmitters with ubiquitous presynaptic release and postsynaptic reception. 5-HT has been implicated in a wide variety of brain functions, ranging from autonomic regulation, sensory perception, feeding and motor function to emotional regulation and cognition. The role of this neuromodulator in neuropsychiatric diseases is unquestionable with important neuropsychiatric medications, e.g., most antidepressants, targeting this system. Importantly, 5-HT modulates neurodevelopment and changes in its levels during development can have life-long consequences. In this mini-review, we highlight that exposure to both low and high serotonin levels during the perinatal period can lead to behavioral deficits in adulthood. We focus on three exogenous factors that can change 5-HT levels during the critical perinatal period: dietary tryptophan depletion, exposure to serotonin-selective-reuptake-inhibitors (SSRIs) and poor early life care. We discuss the effects of each of these on behavioral deficits in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.