ArticlePLoS neglected tropical diseases2018
Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 85 citations in OpenAlex.
- Review
- Identification of typical marker proteins of Treponema pallidum in compact human bone using morphological and biochemical techniques.Scientific reports · 2025Article
- Diagnostic Methods Used in Detecting Syphilis in Paleopathological Research-A Literature Review.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- [Origin of Syphilis in Europe: End of a Controversy?]Medecine tropicale et sante internationale · 2025Article
- Insights into Treponema pallidum genomics from modern and ancient genomes using a novel mapping strategy.BMC biology · 2025Article
- Decoding and Unravelling Mpox, Herpes, and Syphilis Infections: A State of Art Review.Current pharmaceutical biotechnology · 2025Review
- Metagenomic and paleopathological analyses of a historic documented collection explore ancient dental calculus as a diagnostic tool.Scientific reports · 2024Article
- Article
- Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens.Epidemiologia (Basel, Switzerland) · 2022Review
- HAYSTAC: A Bayesian framework for robust and rapid species identification in high-throughput sequencing data.PLoS computational biology · 2022Article
- Genomics of Ancient Pathogens: First Advances and Prospects.Biochemistry. Biokhimiia · 2022Review
- An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.Genome biology · 2022Article
- Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum.Molecular biology and evolution · 2022Article
- Article
- Article
- Human major infections: Tuberculosis, treponematoses, leprosy-A paleopathological perspective of their evolution.PloS one · 2021Article
- Paleogenomic insights into the red complex bacteriaPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Geographically structured genomic diversity of non-human primate-infectingMicrobial genomics · 2020Article
- The Recovery, Interpretation and Use of Ancient Pathogen Genomes.Current biology : CB · 2020Review
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treponema pallidum infections occur worldwide causing, among other diseases, syphilis and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious disease with millions of new infections annually. Here we present three historic T. pallidum genomes (two from T. pallidum ssp. pallidum and one from T. pallidum ssp. pertenue) that have been reconstructed from skeletons recovered from the Convent of Santa Isabel in Mexico City, operational between the 17th and 19th century. Our analyses indicate that different T. pallidum subspecies caused similar diagnostic presentations that are normally associated with syphilis in infants, and potential evidence of a congenital infection of T. pallidum ssp. pertenue, the causative agent of yaws. This first reconstruction of T. pallidum genomes from archaeological material opens the possibility of studying its evolutionary history at a resolution previously assumed to be out of reach.
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