ReviewCellular and molecular neurobiology1985
A possible mechanism of morphometric changes in dendritic spines induced by stimulation.
Review in Cellular and molecular neurobiology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 106 citations in OpenAlex.
- The temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines.iScience · 2023Article
- Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels.Frontiers in cellular neuroscience · 2023Article
- KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization.eLife · 2022Article
- 5-HT6R null mutatrion induces synaptic and cognitive defects.Aging cell · 2021Article
- Mechanical Principles Governing the Shapes of Dendritic Spines.Frontiers in physiology · 2021Article
- Circadian Changes of Dendritic Spine Geometry in Mouse Barrel Cortex.Frontiers in neuroscience · 2020Article
- Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium.The Journal of general physiology · 2019Article
- Dendritic spine plasticity as an underlying mechanism of neuropathic pain: commentary on Tan et al.Experimental neurology · 2012Article
- Long-term potentiation-dependent spine enlargement requires synaptic Ca2+-permeable AMPA receptors recruited by CaM-kinase I.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Interfering with the actin network and its effect on long-term potentiation and synaptic tagging in hippocampal CA1 neurons in slices in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- A novel mechanism of dendritic spine plasticity involving estradiol induction of prostaglandin-E2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Expression of synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy.Brain pathology (Zurich, Switzerland) · 2001Article
- Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons.The Journal of cell biology · 1999Article
- The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Induction of neuron-specific tropomyosin mRNAs by nerve growth factor is dependent on morphological differentiation.The Journal of cell biology · 1993Article
- Kindling is associated with the formation of novel mossy fibre synapses in the CA3 region.Experimental brain research · 1992Article
- Morphology of a sensory neuron in Drosophila is abnormal in memory mutants and changes during aging.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Chromatolysis of dorsal root ganglion cells studied by cryofixation.Cell and tissue research · 1989Article
- Activity-dependent synaptic stabilization in development and learning: how similar the mechanisms?Cellular and molecular neurobiology · 1985Article
- Synaptic architectonics of the molecular layer of the cerebral cortex of rats during audiogenic epileptiform attacks against the background of regulation of the level of cerebral convulsive readiness.Neuroscience and behavioral physiologyArticle
Corrections and comments
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1 author at 1 institution in 1 country.
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Abstract
A number of experimental procedures which induce increased electrical activity (including long-term potentiation) were shown to be accompanied by morphometric changes in dendritic spines. These changes include an enlargement of the spine head, shortening and widening of the spine stalk, and an increase in the length of synaptic apposition. A possible mechanism is suggested which takes into account specific cytological features of the spine and the existence of contractile proteins in neurons. Dendritic spines are defined as special domains of the neuron which have a unique organization of the cytoplasm. Actin filaments form a very dense network in the spine head, and they are longitudinally organized within the spine stalk. Spines were also shown to contain myosin and other actin-regulatory proteins. The high density of the actin network could explain the characteristic absence of the cytoplasmic organelles from dendritic spines. In analogy with other cells, such an actin organization indicates low levels of free cytosolic calcium. Even in the resting state, calcium levels may be unevenly distributed through the neuron, being lowest within the subplasmalemmal region. Due to the high surface-to-volume ratio in spines, the cytoplasm is formed mostly by the subplasmalemmal region. The spine apparatus or the smooth endoplasmic reticulum, which is recognized as a calcium-sequestering site in spines, may also contribute to the low calcium levels there. However, when in the stimulated spine the voltage-dependent calcium channels open, then, given the spine's high surface-to-volume ratio, the concentration of calcium may very quickly attain levels that will activate the actin-regulatory proteins and myosin and thus trigger the chain of events leading to the enlargement of the spine head and to the contraction (i.e., widening and shortening) of the spine stalk. The increased free cytosolic calcium may also activate the protein-producing system localized at the base of the spine, which, under certain conditions, could stabilize the morphometric changes of the spine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.