ArticleThe British journal of radiology2018
ADC histogram analysis of muscle lymphoma-correlation with histopathology in a rare entity.
Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- MRI characteristics of appendicular soft tissue lymphoma: a retrospective analysis.World journal of surgical oncology · 2026Article
- Article
- Associations between apparent diffusion coefficient values and histopathological tissue alterations in myopathies.Brain and behavior · 2020Article
- Apparent Diffusion Coefficient Histogram Analysis for Assessing Tumor Staging and Detection of Lymph Node Metastasis in Epithelial Ovarian Cancer: Correlation with p53 and Ki-67 Expression.Molecular imaging and biology · 2019Article
- Whole-lesion ADC histogram analysis is not able to reflect microvessel density in HNSCC.Medicine · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective: Diffusion-weighted imaging is able to reflect histopathology architecture. A novel imaging approach, namely histogram analysis, is used to further characterize lesion on MRI. To correlate histogram parameters derived from apparent diffusion coefficient (ADC) maps with histopathology parameters in muscle lymphoma.
methods: Eight patients (mean age 64.8 years, range 45-72 years) with histopathologically confirmed muscle lymphoma were retrospectively identified. Cell count, total nucleic and average nucleic areas were estimated using ImageJ. Additionally, Ki67-index was calculated. Diffusion-weightedimaging was obtained on a 1.5 T scanner by using the b-values of 0 and 1000 s mm
results: All ADC parameters showed a good to excellent interreader variability. Cell count correlated well with ADCmean (ρ = -0.76, p = 0.03) and ADCp75 (ρ =-0.79, p = 0.02). Kurtosis and entropy correlated with average nucleic area (ρ = -0.81, p = 0.02, ρ =0.88, p = 0.007, respectively). None of the analyzed ADC parameters correlated with total nucleic area and with Ki67-index.
conclusion: ADC histogram analysis parameters can reflect cellularity in muscle lymphoma. ADVANCES IN KNOWLEDGE:: Histogram parameters derived from ADC maps can reflect several different cellularity parameters in muscle lymphoma.
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