ArticleThe American journal of sports medicine2018
Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.
Article in The American journal of sports medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Lactate metabolism and protein lactylation in inflammatory and tumor microenvironments.Molecular biomedicine · 2026Review
- Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytes.Bone research · 2026Article
- Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications.Signal transduction and targeted therapy · 2026Review
- Turmeric-derived extracellular vesicles loaded microneedle system attenuates rotator cuff degeneration by orchestrating energetic metabolism.Materials today. Bio · 2025Article
- Biodegradable metabotissugenic citrate-based polymer derived self-sealing pro-regenerative membrane for tendon anti-biofouling and repair.Bioactive materials · 2025Article
- Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Radiation-induced changes in energy metabolism result in mitochondrial dysfunction in salivary glands.Scientific reports · 2024Article
- Itaconate-producing neutrophils regulate local and systemic inflammation following trauma.JCI insight · 2023Article
- Metabolic regulation of intrasynovial flexor tendon repair: The effects of dichloroacetate administration on early tendon healing in a canine model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Inhibition of glucose use improves structural recovery of injured Achilles tendon in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Untargeted metabolomics analysis identifies creatine, myo-inositol, and lipid pathway modulation in a murine model of tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Metabolic Regulation of Tendon Inflammation and Healing Following Injury.Current rheumatology reports · 2021Review
- Basic Research on Tendon Repair: Strategies, Evaluation, and Development.Frontiers in medicine · 2021Review
- Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing.Journal of orthopaedic translation · 2020Article
- Adipose-derived stem cells improve tendon repair and prevent ectopic ossification in tendinopathy by inhibiting inflammation and inducing neovascularization in the early stage of tendon healing.Regenerative therapy · 2020Article
- Spectrum of Tendon Pathologies: Triggers, Trails and End-State.International journal of molecular sciences · 2020Review
- Control of glucose metabolism is important in tenogenic differentiation of progenitors derived from human injured tendons.PloS one · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundTendon injuries are common problems among athletes. Complete recovery of the mechanical structure and function of ruptured tendons is challenging. It has been demonstrated that upregulation of glycolysis and lactate production occurs in wounds, inflammation sites, and cancerous tumors, and these metabolic changes also control growth and differentiation of stem and progenitor cells. Similar metabolic changes have been reported in human healing tendons. In addition, lactate production has increased in progenitors isolated from injured tendons after treatment with IL-1β. It is thought that the metabolic changes play a role in tendon healing after injury. HYPOTHESIS: Glucose metabolism is altered during tendon injury and healing, and modulation of this altered metabolism improves tendon repair. STUDY
designControlled laboratory study.
methodsThe authors used the tendon injury model involving a complete incision of the Achilles tendon in C57BL/6J female mice and studied alterations of glucose metabolism in injured tendons with [U-
resultsSignificant changes in glucose metabolism in tendons after injury surgery were detected.
conclusionThe findings indicate that injured tendons acutely increase glycolysis and lactate synthesis after injury and that the inhibition of lactate synthesis by DCA is beneficial for tendon healing. CLINICAL RELEVANCE: Changing metabolism in injured tendons may be a therapeutic target for tendon repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.