ArticleJornal brasileiro de nefrologia
The influence of clinical, environmental, and socioeconomic factors on five-year patient survival after kidney transplantation.
Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Infections in the first year of living related kidney transplantation in a young transplant cohort.BMC nephrology · 2023Observational
- Effect of Carbapenem-ResistantInfection and drug resistance · 2022Article
- Impact of Combinations of Donor and Recipient Ages and Other Factors on Kidney Graft Outcomes.Frontiers in immunology · 2020Article
- Understanding the causes of mortality post-transplantation - there is more than meets the eye.Jornal brasileiro de nefrologiaArticle
- Impact of pretransplantation malnutrition risk on the clinical outcome and graft survival of kidney transplant patients.Jornal brasileiro de nefrologiaArticle
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12 authors.
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Abstract
introductionThe risk of death after kidney transplant is associated with the age of the recipient, presence of comorbidities, socioeconomic status, local environmental characteristics and access to health care.
objectiveTo investigate the causes and risk factors associated with death during the first 5 years after kidney transplantation.
methodsThis was a single-center, retrospective, matched case-control study.
resultsUsing a consecutive cohort of 1,873 kidney transplant recipients from January 1st 2007 to December 31st 2009, there were 162 deaths (case group), corresponding to 5-year patient survival of 91.4%. Of these deaths, 25% occurred during the first 3 months after transplant. The most prevalent cause of death was infectious (53%) followed by cardiovascular (24%). Risk factors associated with death were history of diabetes, dialysis type and time, unemployment, delayed graft function, number of visits to center, number of hospitalizations, and duration of hospital stay. After multivariate analysis, only time on dialysis, number of visits to center, and days in hospital were still associated with death. Patients who died had a non-significant higher number of treated acute rejection episodes (38% vs. 29%, p = 0.078), higher mean number of adverse events per patient (5.1 ± 3.8 vs. 3.8 ± 2.9, p = 0.194), and lower mean eGFR at 3 months (50.8 ± 25.1 vs. 56.7 ± 20.7, p = 0.137) and 48 months (45.9 ± 23.8 vs. 58.5 ± 20.2, p = 0.368).
conclusionThis analysis confirmed that in this population, infection is the leading cause of mortality over the first 5 years after kidney transplantation. Several demographic and socioeconomic risk factors were associated with death, most of which are not readily modifiable.
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