ArticleMolecular biology of the cell2018
Actomyosin stress fiber subtypes have unique viscoelastic properties and roles in tension generation.
Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment.bioRxiv : the preprint server for biology · 2026Article
- Enhancement of Cytoskeletal Tension Promotes Amyloid-β Aggregation on the Neuronal Cell Surface.Molecules (Basel, Switzerland) · 2026Article
- Theory of active self-organization of dense nematic structures in the actin cytoskeleton.eLife · 2025Article
- Bioenergetic responses to β-adrenergic stimulation in beige adipocyte depend on actomyosin driven forces.bioRxiv : the preprint server for biology · 2025Article
- Article
- Sustained strain applied at high rates drives dynamic tensioning in epithelial cells.Communications biology · 2025Article
- Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells.bioRxiv : the preprint server for biology · 2025Article
- Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton.Nature communications · 2023Article
- The actin cytoskeleton: Morphological changes in pre- and fully developed lung cancer.Biophysics reviews · 2022Review
- Unravelling cell migration: defining movement from the cell surface.Cell adhesion & migration · 2022Review
- Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments.Nature communications · 2022Article
- Merging of ventral fibers at adhesions drives the remodeling of cellular contractile systems in fibroblasts.Cytoskeleton (Hoboken, N.J.) · 2022Article
- Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing.Nature communications · 2021Article
- Article
- Actin-based force generation and cell adhesion in tissue morphogenesis.Current biology : CB · 2021Review
- EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization.Nature communications · 2021Article
- Transduction of cell and matrix geometric cues by the actin cytoskeleton.Current opinion in cell biology · 2021Review
- Article
- Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation.Biomolecules · 2020Review
- Inhibition of focal adhesion kinase increases myofibril viscosity in cardiac myocytes.Cytoskeleton (Hoboken, N.J.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Actomyosin stress fibers (SFs) support cell shape and migration by directing intracellular tension to the extracellular matrix (ECM) via focal adhesions. Migrating cells exhibit three SF subtypes (dorsal SFs, transverse arcs, and ventral SFs), which differ in their origin, location, and ECM connectivity. While each subtype is hypothesized to play unique structural roles, this idea has not been directly tested at the single-SF level. Here, we interrogate the mechanical properties of single SFs of each subtype based on their retraction kinetics following laser incision. While each SF subtype bears distinct mechanical properties, these properties are highly interdependent, with incision of dorsal fibers producing centripetal recoil of adjacent transverse arcs and the retraction of incised transverse arcs being limited by attachment points to dorsal SFs. These observations hold whether cells are allowed to spread freely or are confined to crossbow ECM patterns. Consistent with this interdependence, subtype-specific knockdown of dorsal SFs (palladin) or transverse arcs (mDia2) influences ventral SF retraction. These altered mechanics are partially phenocopied in cells cultured on ECM microlines that preclude assembly of dorsal SFs and transverse arcs. Our findings directly demonstrate that different SF subtypes play distinct roles in generating tension and form a mechanically interdependent network.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.