ArticleJournal of abnormal psychology2018
Estrogen moderates genetic influences on binge eating during puberty: Disruption of normative processes?
Article in Journal of abnormal psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04225221 (Ovarian Hormones, Reward Response, and Binge Eating in Bulimia Nervosa), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ovarian Hormones, Reward Response, and Binge Eating in Bulimia Nervosa: An Experimental Design
Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- The contribution of genetic and environmental influences underlying disordered eating to exposure to weight-conscious peers.Psychological medicine · 2026Article
- Gondal hormones and binge eating in females: developmental and etiologic insights from puberty to adulthood.Current opinion in psychiatry · 2025Review
- Distinct Topological Properties of the Reward Anticipation Network in Preadolescent Children With Binge Eating Disorder Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Temperament impact on eating disorder symptoms and habit formation: a novel model to inform treatment.Journal of eating disorders · 2024Review
- Article
- Estrogen moderation of genetic influences on eating disorder symptoms during gonadarche in girls: Specific effects on binge eating.Psychoneuroendocrinology · 2023Article
- The organizational role of ovarian hormones during puberty on risk for binge-like eating in rats.Physiology & behavior · 2023Review
- Neurodevelopmental Model Explaining Associations between Sex Hormones, Personality, and Eating Pathology.Brain sciences · 2023Review
- Gender and sex in eating disorders: A narrative review of the current state of knowledge, research gaps, and recommendations.Brain and behavior · 2023Review
- Epidemiology of eating disorders: population, prevalence, disease burden and quality of life informing public policy in Australia-a rapid review.Journal of eating disorders · 2023Review
- Binge Eating Risk During Midlife and the Menopausal Transition: Sensitivity to Ovarian Hormones as Potential Mechanisms of Risk.Current psychiatry reports · 2023Review
- Practical Considerations for Using the Eating Disorder Examination Interview with Adolescents.Adolescent health, medicine and therapeutics · 2023Review
- Disadvantage and disordered eating in boys: Examining phenotypic and genotype × environment associations across development.Journal of psychopathology and clinical science · 2023Article
- Editorial: The critical need to assess pubertal development in studies of child and adolescent psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- An investigation of associations between parenting and binge eating across pubertal development in pre-adolescent and adolescent female participants.The International journal of eating disorders · 2022Article
- Exploring the possibility of parents' broad internalizing phenotype acting through passive gene-environment correlations on daughters' disordered eating.Development and psychopathology · 2022Article
- How nonshared environmental factors come to correlate with heredity.Development and psychopathology · 2022Article
- Context matters: Neighborhood disadvantage is associated with increased disordered eating and earlier activation of genetic influences in girls.Journal of abnormal psychology · 2021Article
- Gonadal Hormone Influences on Sex Differences in Binge Eating Across Development.Current psychiatry reports · 2021Review
- The effects of puberty on associations between mood/personality factors and disordered eating symptoms in girls.The International journal of eating disorders · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Puberty is a critical period for changes in genetic effects for binge eating in girls. Previous twin studies show increases in genetic influences on binge eating from prepuberty (∼0%) to midpuberty and beyond (∼50%). However, little is known about the factors that drive these shifts in genetic effects. A small pilot study showed that pubertal activation of estrogen may contribute to increases in genetic influences, possibly via hormonally induced changes in gene expression. However, large-scale studies investigating hormone effects on genetic risk are lacking. Thus, the purpose of the present study was to examine the effects of estrogen on genetic influences for binge eating in 964 female twins (ages 8-16 years) from the Michigan State University Twin Registry. Binge eating was assessed with the Minnesota Eating Behaviors Survey, whereas afternoon saliva samples were assayed for estradiol levels using standard enzyme immunoassays. Twin moderation models showed substantial differences in genetic influences on binge eating across estradiol levels. Stronger genetic effects were observed at lower (rather than higher) estradiol levels, even when controlling for the effects of age, body mass index, the physical changes of puberty, and the onset of menses. Overall, findings suggest that comparatively lower levels of estradiol during this critical period may disrupt normative developmental processes and enhance genetic influences on binge eating. (PsycINFO Database Record
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.