Evidence map›Paper›PMID 29927098›Full record

ArticleCurrent protocols in stem cell biology2018

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.

Dan C Wilkinson, Michael Mellody, Luisa K Meneses, Ashley C Hope, Bruce Dunn, Brigitte N Gomperts

Abstract read
In one paragraph

Article in Current protocols in stem cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Engineering Dynamic 3D Models of Lung.Advances in experimental medicine and biology · 2023
    Article
  5. Harnessing mechanobiology for kidney organoid research.Frontiers in cell and developmental biology · 2023
    Review
  6. Towards organoid culture without Matrigel.Communications biology · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Application of iPSC to Modelling of Respiratory Diseases.Advances in experimental medicine and biology · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dan C WilkinsonDepartment of Materials Science and Engineering, UCLA, Los Angeles, California.
Michael MellodyDepartment of Bioengineering, UCLA, Los Angeles, California.
Luisa K MenesesUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California.
Ashley C HopeUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California.
Bruce DunnDepartment of Materials Science and Engineering, UCLA, Los Angeles, California.
Brigitte N GompertsUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California.

Funding

MARC U*STAR Program at the University of California, Los AngelesT34GM008563 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCEVOY, MEGAN M, POE, GINA R · 1996 to 2023
$9.7M
Developing a targeted chemoprevention strategy for Non-Small Cell Lung CancerR01CA208303 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMPERTS, BRIGITTE N · 2016 to 2020
$1.9M
Development of a High-Throughput Screen for Pre-therapeutic Discovery in Idiopathic Pulmonary FibrosisR01GM114259 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAMOISEAUX, ROBERT, GOMPERTS, BRIGITTE N · 2015 to 2017
$1.1M
NCI NIH HHS R01 CA208303NIGMS NIH HHS R01 GM114259NIGMS NIH HHS T34 GM008563
6 · The paper itself

Abstract

This unit describes a protocol for generation of lung organoids. A lung organoid is a 3D cell/hydrogel composite that resembles the morphology and cellular composition of the human distal lung. These tissue-engineered constructs provide an in vitro model of human lung and are best suited for disease modeling applications. The organoid generation methodology is flexible, allowing for easy scalability in the number of organoids produced and in the ability to accommodate a wide range of cell types. © 2018 by John Wiley & Sons, Inc.

Indexed as

Imaging, Three-DimensionalPrecision MedicineAlginatesAnimalsBioengineeringBioreactorsCollagen Type IFibroblastsLungMicrospheresOrganoidsRatsStatic ElectricityAlginatesCollagen Type I3-D cell culturedistal airwaylung disease modelingpluripotent stem cellstissue engineering

Identifiers

PMID29927098
PMCPMC6105393

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.