Evidence map›Paper›PMID 29927055›Full record

ArticleVeterinary ophthalmology2019

Effects of 5% sodium chloride ophthalmic ointment on thickness and morphology of the normal canine cornea.

Michelle Samuel, Sara M Thomasy, Allison S Calderon, Philip H Kass, Keith Collins, Christopher J Murphy

Open access · greenAbstract readClinical Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michelle SamuelEye Care for Animals, Pewaukee, WI, USA.
Sara M ThomasyDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Allison S CalderonDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Philip H KassDepartment of Population Health and Reproduction, School of Veterinary Medicine and School of Medicine, University of California, Davis, CA, USA.
Keith CollinsEye Care for Animals, Pewaukee, WI, USA.
Christopher J MurphyDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
University of California, Davis · USEye Care Associates · US

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI LISA M OAKES · 1999 to 2026
$18.9M
Biophysical Cues and Corneal Wound HealingR01EY019970 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MURPHY, CHRISTOPHER JOHN · 2011 to 2020
$3.5M
Engineering the Corneal Wound Bed to Promote HealingK08EY021142 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI THOMASY, SARA MICHELLE · 2011 to 2015
$879k
Akorn Animal HealthCenter for Companion Animal Health, School of Veterinary Medicine, University of California, Davis 2013-19-FEye Care for Animals Research FundNational Eye Institute K08 EY021142National Eye Institute P30 EY12576National Eye Institute R01 EY019970NEI NIH HHS K08 EY021142NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY019970Research to Prevent BlindnessUC Davis Academic Federation Innovative Development Award
6 · The paper itself

Abstract

objectiveTo determine the effect of 5% sodium chloride ophthalmic ointment (5% NaCl) on thickness and morphology of the normal canine cornea using ultrasonic pachymetry (USP), in vivo confocal microscopy (IVCM), and Fourier-domain optical coherence tomography (FD-OCT).

methodsFive healthy laboratory Beagles received ophthalmic examinations including USP, IVCM, and FD-OCT prior to and at fixed intervals following treatment. The right and left eyes were treated with 5% NaCl and artificial tears ophthalmic ointment (AT), respectively, every 2 hours for 4 treatments/d (days 2-9), and then hourly for 7 treatments/d (day 10). Treatment groups were statistically compared using mixed-effects linear regression.

resultsTreatment with 5% NaCl resulted in a 12 μm decrease in corneal thickness from baseline (P < .001), while there was no significant difference in corneal thickness between values obtained at baseline and following treatment with AT (P = .82). Epithelial cell density significantly increased from baseline (530 ± 52 cells/mm

conclusionsShort-term topical treatment with 5% NaCl decreased corneal thickness in normal dogs with no observable changes in corneal morphology or signs of ocular toxicity.

Indexed as

AnimalsCorneaDog DiseasesDogsDry Eye SyndromesFemaleLubricant Eye DropsOintmentsOphthalmic SolutionsRandom AllocationSaline SolutionTreatment OutcomeLubricant Eye DropsOintmentsOphthalmic SolutionsSaline Solution5% sodium chloride ophthalmic ointmentcaninecorneal edemain vivo confocal microscopyoptical coherence tomographyultrasonic pachymetry

Identifiers

PMID29927055
PMCPMC6309519
OpenAlexW2809154083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.