Evidence map›Paper›PMID 29927039›Full record

ArticlePediatric diabetes2018

Diabetes management mediating effects between diabetes symptoms and health-related quality of life in adolescents and young adults with type 1 diabetes.

James W Varni, Alan M Delamater, Korey K Hood, Kimberly A Driscoll, Jenise C Wong, Saleh Adi, Joyce P Yi-Frazier, Ellen K Grishman, Melissa A Faith, Sarah D Corathers and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

James W VarniDepartment of Pediatrics, College of Medicine, Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A&M University, College Station, Texas.ORCID 0000-0003-4816-4357
Alan M DelamaterDepartment of Pediatrics, Mailman Center for Child Development, University of Miami Miller School of Medicine, Miami, Florida.
Korey K HoodDivision of Pediatric Endocrinology and Diabetes, Stanford University School of Medicine, Stanford, California.
Kimberly A DriscollDepartment of Pediatrics, Barbara Davis Center for Diabetes, University of Colorado Denver, Denver, Colorado.
Jenise C WongThe Madison Clinic for Pediatric Diabetes and Department of Pediatrics, Division of Endocrinology, University of California San Francisco, San Francisco, California.
Saleh AdiThe Madison Clinic for Pediatric Diabetes and Department of Pediatrics, Division of Endocrinology, University of California San Francisco, San Francisco, California.
Joyce P Yi-FrazierSeattle Children's Research Institute, Seattle, Washington.ORCID 0000-0002-7057-7249
Ellen K GrishmanDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas.
Melissa A FaithDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas.
Sarah D CorathersDepartment of Pediatrics, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Jessica C KichlerDepartment of Pediatrics, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Jennifer L MillerDivision of Pediatric Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Jennifer K RaymondCenter for Endocrinology, Diabetes, & Metabolism, Children's Hospital Los Angeles, Los Angeles, California.
Elena M DoskeyDepartment of Educational Psychology, Texas A&M University, College Station, Texas.
Vincent AguirreDepartment of Psychological and Brain Sciences, Texas A&M University, College Station, Texas.
Robert W HefferDepartment of Psychological and Brain Sciences, Texas A&M University, College Station, Texas.
Don P WilsonCook Children's Medical Center, Fort Worth, Texas.
Pediatric Quality of Life Inventory 3.2 Diabetes Module Testing Study Consortium

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Optimizing Patient Use of Devices and Data in Early Adolescents with Type 1 DiabetesK23DK107894 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WONG, JENISE C · 2015 to 2017
$586k
NIDDK NIH HHS K23 DK107894NIDDK NIH HHS P30 DK116074
6 · The paper itself

Abstract

objectivesThe primary objective was to investigate the mediating effects of diabetes management in the relationship between diabetes symptoms and generic health-related quality of life (HRQOL) in adolescents and young adults (AYAs) with type 1 diabetes. The secondary objective explored patient health communication and perceived treatment adherence barriers as mediators in a serial multiple mediator model.

methodsThe PedsQL 3.2 Diabetes Module 15-item diabetes symptoms summary score, 18-item diabetes management summary score, and PedsQL 4.0 generic core scales were completed in a 10-site national field test study by 418 AYA aged 13 to 25 years with type 1 diabetes. Diabetes symptoms and diabetes management were tested for bivariate and multivariate linear associations with overall generic HRQOL. Mediational analyses were conducted to test the hypothesized mediating effects of diabetes management as an intervening variable between diabetes symptoms and generic HRQOL.

resultsThe predictive effects of diabetes symptoms on HRQOL were mediated in part by diabetes management. In predictive analytics models utilizing multiple regression analyses, demographic and clinical covariates, diabetes symptoms, and diabetes management significantly accounted for 53% of the variance in generic HRQOL (P < 0.001), demonstrating a large effect size. Patient health communication and perceived treatment adherence barriers were significant mediators in an exploratory serial multiple mediator model.

conclusionsDiabetes management explains in part the effects of diabetes symptoms on HRQOL in AYA with type 1 diabetes. Patient health communication to healthcare providers and perceived treatment adherence barriers further explain the mechanism in the relationship between diabetes symptoms and overall HRQOL.

Indexed as

Disease ManagementQuality of LifeAdolescentDiabetes Mellitus, Type 1Factor Analysis, StatisticalFemaleHealth CommunicationHumansMaleSurveys and QuestionnairesTreatment Adherence and ComplianceYoung Adulthealth-related quality of lifepatient-reported outcomespediatricsPedsQLself-managementsymptomstype 1 diabetes

Identifiers

PMID29927039
PMCPMC6641859

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.