ArticleMedical physics2018
Impact of advanced detector technology and iterative reconstruction on low-dose quantitative assessment of lung computed tomography density in a biological lung model.
Article in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Institutional CT dose reduction: A retrospective evaluation of dose indices from 2015-2024.Journal of applied clinical medical physics · 2026Article
- Ultra-high Resolution Photon Counting Detector Computed Tomography Imaging for Quantitative Lung Assessment: An Anthropomorphic Phantom Study.Investigative radiology · 2026Article
- Harmonized low-dose computed tomographic protocols for quantitative lung imaging using dose modulation and advanced reconstructions.Medical physics · 2025Article
- Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- CT trachea surface roughness is associated with chronic obstructive pulmonary disease symptoms.Radiology advances · 2024Article
- Meaningful Endpoints for Idiopathic Pulmonary Fibrosis (IPF) Clinical Trials: Emphasis on 'Feels, Functions, Survives'. Report of a Collaborative Discussion in a Symposium with Direct Engagement from Representatives of Patients, Investigators, the National Institutes of Health, a Patient Advocacy Organization, and a Regulatory Agency.American journal of respiratory and critical care medicine · 2024Article
- Multi-slice computed tomographic analysis and identification of remarkable anatomical types of segmental bronchi in bilateral inferior lobes: based on extensive data.Quantitative imaging in medicine and surgery · 2023Article
- Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2023Article
- Menstrual cycle impacts lung structure measures derived from quantitative computed tomography.European radiology · 2022Article
- Origins of and lessons from quantitative functional X-ray computed tomography of the lung.The British journal of radiology · 2022Review
- Case Studies in Physiology: Temporal variations of the lung parenchyma and vasculature in asymptomatic COVID-19 pneumonia: a multispectral CT assessment.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Factors Affecting Radiation Dose in Computed Tomography Angiograms for Pulmonary Embolism: A Retrospective Cohort Study.Journal of clinical imaging science · 2020Article
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9 authors.
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Abstract
purposeQuantitative computed tomography (QCT)-derived measures of lung density are valued methods for objectively characterizing lung parenchymal and peripheral airways disease and are being used in a growing number of lung disease focused trials. Detector and reconstruction improvements in CT technology have allowed for significant radiation dose reduction in image acquisition with comparable qualitative image quality. We report the impact of detector type and reconstruction type on QCT lung density measures in relation to decreasing dose indices.
methodsTwo sets of studies were completed in an in vivo pig model with a SOMATOM Definition Flash CT system: (a) prior to system upgrade with conventional detectors (UFC) and filtered back projection (FBP), and (b) post system upgrade with integrated electronic detectors (STELLAR) and iterative reconstruction (SAFIRE). CT data were acquired across estimated CT volume dose indices (CTDI
resultsIn this study, STELLAR detectors improved concordance with 15 mGy values down to 3 mGy for inspiratory scans and 6 mGy for expiratory scans. The addition of SAFIRE reconstruction in all acquired measurements resulted in minimal deviation from reference values at 0.75 mGy.
conclusionThe use of STELLAR integrated electronic detectors and SAFIRE iterative reconstruction may allow for comparable lung density measures with CT dose indices down to 0.75 mGy.
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