Evidence map›Paper›PMID 29926844›Full record

ReviewActa pharmacologica Sinica2018

Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases.

Sangyong Choi, Xian Liu, Zui Pan

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmacologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 7 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 7 syntheses or guidelines pooled it, 393 citations in OpenAlex.

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  15. ZIP1 Is a Critical DNA Damage-Responsive Zinc Transporter Induced by Bleomycin via the TNFα-NF-κB Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  16. Biological and mechanistic effects of selenium and zinc in coronary artery bypass surgery: preoperative and postoperative evaluation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
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132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sangyong ChoiCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, USA, TX.
Xian LiuCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, USA, TX.
Zui PanCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, USA, TX. zui.pan@uta.edu.
The University of Texas at Arlington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-inflammatory functions. The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury. In this review we summarize the evidence in the literature, to consolidate the current knowledge on the dysregulation of zinc homeostasis in CVDs, and to explore the significant roles of the zinc homeostasis-regulatory proteins in cardiac physiology and pathophysiology. Moreover, this review also deliberates on the potential diagnostic and prognostic implications of zinc/zinc homeostasis-associated molecules (ZIP, ZnT, and MTs) in CVDs.

Indexed as

Oxidative StressAnimalsCardiovascular DiseasesHomeostasisHumansZincZincatherosclerosiscardiovascular diseasesinflammationIrt-like protein (ZIP)metallothionein (MT)ROSzinc homeostasiszinc transporter (ZnT)Zrt

Identifiers

PMID29926844
PMCPMC6289396
OpenAlexW2809136657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.