Evidence map›Paper›PMID 29926817›Full record

ReviewNeural regeneration research2018

How random is the random forest? Random forest algorithm on the service of structural imaging biomarkers for Alzheimer's disease: from Alzheimer's disease neuroimaging initiative (ADNI) database.

Stavros I Dimitriadis, Dimitris Liparas, Alzheimer's Disease Neuroimaging Initiative

Open access · goldAbstract readReview
In one paragraph

Review in Neural regeneration research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 79 citations in OpenAlex.

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  18. GIRUS-net: A Multimodal Deep Learning Model Identifying Imaging and Genetic Biomarkers Linked to Alzheimer's Disease Severity.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023
    Article
  19. Article
  20. WebGIS-Based Real-Time Surveillance and Response System for Vector-Borne Infectious Diseases.International journal of environmental research and public health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Stavros I DimitriadisDivision of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University; Cardiff University Brain Research Imaging Centre, School of Psychology; School of Psychology; Neuroinformatics Group, Cardiff University Brain Research Imaging Centre, School of Psychology; Neuroscience and Mental Health Research Institute; MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff, UK.
Dimitris LiparasHigh Performance Computing Center Stuttgart (HLRS), University of Stuttgart, Stuttgart, Germany; Department of Informatics, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Alzheimer's Disease Neuroimaging Initiative
Cardiff University · GBUniversity of Stuttgart · DE

Funding

Medical Research Council MR/K004360/1
6 · The paper itself

Abstract

Neuroinformatics is a fascinating research field that applies computational models and analytical tools to high dimensional experimental neuroscience data for a better understanding of how the brain functions or dysfunctions in brain diseases. Neuroinformaticians work in the intersection of neuroscience and informatics supporting the integration of various sub-disciplines (behavioural neuroscience, genetics, cognitive psychology, etc.) working on brain research. Neuroinformaticians are the pathway of information exchange between informaticians and clinicians for a better understanding of the outcome of computational models and the clinical interpretation of the analysis. Machine learning is one of the most significant computational developments in the last decade giving tools to neuroinformaticians and finally to radiologists and clinicians for an automatic and early diagnosis-prognosis of a brain disease. Random forest (RF) algorithm has been successfully applied to high-dimensional neuroimaging data for feature reduction and also has been applied to classify the clinical label of a subject using single or multi-modal neuroimaging datasets. Our aim was to review the studies where RF was applied to correctly predict the Alzheimer's disease (AD), the conversion from mild cognitive impairment (MCI) and its robustness to overfitting, outliers and handling of non-linear data. Finally, we described our RF-based model that gave us the 1

Indexed as

Alzheimer's diseasebiomarkerclassificationmachine learningmagnetic resonance imagingmild cognitive impairmentneuroimagingrandom forest

Identifiers

PMID29926817
PMCPMC6022472
OpenAlexW2800206746

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.