Evidence map›Paper›PMID 29926357›Full record

Trial reportObesity surgery2018

Preperitoneal Bupivacaine Infiltration Reduces Postoperative Opioid Consumption, Acute Pain, and Chronic Postsurgical Pain After Bariatric Surgery: a Randomized Controlled Trial.

Saskia L Boerboom, Ann de Haes, Lianne Vd Wetering, Edo O Aarts, Ignace M C Janssen, Jose W Geurts, Ed T Kamphuis

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03975283 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

Use of Long-acting Local Analgesia in Bariatrics: A Randomized Controlled Trial

TypeinterventionalSponsorMcMaster UniversityRan2019 to 2021Enrolled80ConditionsPost Operative PainArmsExparel 266 MG Per 20 ML Injection, Bupivacaine Hcl 0.25% Inj
NCT04680923 nacompletednot on this mapstarted 2020, after this paper: background citation

Efficacy of Combined Periportal and Preperitoneal Local Anesthetic Infiltration (CPPLAI) in Laparoscopic Sleeve Gastrectomy Patients

TypeinterventionalSponsorKing Khalid University HospitalRan2020 to 2021Enrolled120ConditionsObesity, Morbid, Pain, PostoperativeArmsCPPLAI, Placebo, Bupivacaine 0.25%
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Saskia L BoerboomDepartment of Anesthesiology, Rijnstate Hospital, Postbus 9555, 6800 TA, Arnhem, The Netherlands. slboerboom@gmail.com.ORCID 0000-0002-2278-1835
Ann de HaesDepartment of Anesthesiology, Rijnstate Hospital, Postbus 9555, 6800 TA, Arnhem, The Netherlands.
Lianne Vd WeteringDepartment of Anesthesiology, Rijnstate Hospital, Postbus 9555, 6800 TA, Arnhem, The Netherlands.
Edo O AartsDepartment of Surgery, Rijnstate Hospital, Postbus 9555, 6800 TA, Arnhem, The Netherlands.
Ignace M C JanssenDepartment of Surgery, Rijnstate Hospital, Postbus 9555, 6800 TA, Arnhem, The Netherlands.
Jose W GeurtsDepartment of Anesthesiology, Rijnstate Hospital, Postbus 9555, 6800 TA, Arnhem, The Netherlands.
Ed T KamphuisDepartment of Anesthesiology, Rijnstate Hospital, Postbus 9555, 6800 TA, Arnhem, The Netherlands.
Rijnstate Hospital · NLMaastricht University Medical Centre · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA multimodal pain treatment including local anesthetics is advised for perioperative analgesia in bariatric surgery. Due to obesity, bariatric surgery patients are at risk of respiratory complications. Opioid consumption is an important risk factor for hypoventilation. Furthermore, acute postoperative pain is an important risk factor for chronic postsurgical pain. In this study, we aimed to evaluate whether preperitoneal anesthesia with bupivacaine would reduce pain and opioid consumption after bariatric surgery.

methodsOne hundred adults undergoing laparoscopic bariatric surgery were randomized to receive either preperitoneal bupivacaine 0.5% or normal saline before incision. Postoperative opioid consumption, postoperative pain, and postoperative recovery parameters were assessed for the first 24 h after surgery. One year after surgery, chronic postsurgical pain and influence of pain on daily living were evaluated.

resultsPostoperative opioid consumption during the first hour after surgery was 2.8 ± 3.0 mg in the bupivacaine group, whereas in the control group, it was 4.4 ± 3.4 mg (p = 0.01). Pain scores were significantly reduced in this first hour at rest and at 6 h during mobilization on the ward. One year after surgery, the incidence of chronic postsurgical pain was 13% in the bupivacaine group versus 40% in the placebo group.

conclusionThis study shows that preperitoneal local anesthesia with bupivacaine results in a reduction in opioid consumption and postoperative pain and seems to lower the incidence rate of chronic postsurgical pain after laparoscopic bariatric surgery.

Indexed as

Analgesics, OpioidBupivacaineAcute PainAdultAnesthetics, LocalBariatric SurgeryHumansObesity, MorbidOpioid-Related DisordersPostoperative PainPreoperative CareAnalgesics, OpioidAnesthetics, LocalBupivacaineAcute painBupivacaineChronic painGastric bypass surgeryLocal anesthesiaPostoperative pain

Identifiers

PMID29926357
OpenAlexW2809360280

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.