Evidence map›Paper›PMID 29926348›Full record

ArticleEndocrine2018

Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish.

G Montalbano, M Mania, F Abbate, M Navarra, M C Guerrera, R Laura, J A Vega, M Levanti, A Germanà

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  8. The effects of environmental changes on the endocrine regulation of feeding in fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
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  19. Zebrafish and Flavonoids: Adjuvants against Obesity.Molecules (Basel, Switzerland) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

G MontalbanoDepartment of Veterinary Sciences, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy. gmontalbano@unime.it.ORCID http://orcid.org/0000-0002-8195-4986
M ManiaDepartment of Veterinary Sciences, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy.
F AbbateDepartment of Veterinary Sciences, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy.
M NavarraDepartment of Drug Sciences and products for Health, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy.
M C GuerreraDepartment of Veterinary Sciences, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy.
R LauraDepartment of Veterinary Sciences, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy.
J A VegaDepartamento de Morfología y Biología Celular, Universidad de Oviedo, Oviedo, España, 33006, Spain.
M LevantiDepartment of Veterinary Sciences, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy.
A GermanàDepartment of Veterinary Sciences, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy.
University of Messina · ITUniversidad de Oviedo · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOverweight and obesity are important risk factors for diabetes, cardiovascular diseases, and premature death in modern society. Recently, numerous natural and synthetic compounds have been tested in diet-induced obese animal models, to counteract obesity. Melatonin is a circadian hormone, produced by pineal gland and extra-pineal sources, involved in processes which have in common a rhythmic expression. In teleost, it can control energy balance by activating or inhibiting appetite-related peptides. The study aims at testing effects of melatonin administration to control-fed and overfed zebrafish, in terms of expression levels of orexigenic (Ghrelin, orexin, NPY) and anorexigenic (leptin, POMC) genes expression and morphometry of visceral and subcutaneous fat depots.

methodsAdult male zebrafish (n = 56) were divided into four dietary groups: control, overfed, control + melatonin, overfed + melatonin. The treatment lasted 5 weeks and BMI levels of every fish were measured each week. After this period fishes were sacrificed; morphological and morphometric studies have been carried out on histological sections of adipose tissue and adipocytes. Moreover, whole zebrafish brain and intestine were used for qRT-PCR.

resultsOur results demonstrate that melatonin supplementation may have an effect in mobilizing fat stores, in increasing basal metabolism and thus in preventing further excess fat accumulation. Melatonin stimulates the anorexigenic and inhibit the orexigenic signals.

conclusionsIt seems that adequate melatonin treatment exerts anti-obesity protective effects, also in a diet-induced obesity zebrafish model, that might be the result of the restoration of many factors: the final endpoint reached is weight loss and stabilization of weight gain.

Indexed as

AdipocytesAdipose TissueAnimalsAppetiteBody Mass IndexBrain ChemistryCell CountCell SizeDietDisease Models, AnimalGene ExpressionMaleMelatoninNeuropeptide YObesityOrexinsMelatoninNeuropeptide YOrexinsPro-OpiomelanocortinRNA, MessengerAdipose tissue.Diet-induced obesityMelatoninZebrafish

Identifiers

PMID29926348
OpenAlexW2809479433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.