Evidence map›Paper›PMID 29926320›Full record

ArticleMolecular and cellular biochemistry2019

Cellular miR-2909 RNomics governs the genes that ensure immune checkpoint regulation.

Deepak Kaul, Deepti Malik, Sameena Wani

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Deepak KaulMolecular Biology Unit, Experimental Medicine & Biotechnology Department, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India. dkaul_24@hotmail.com.
Deepti MalikMolecular Biology Unit, Experimental Medicine & Biotechnology Department, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.
Sameena WaniMolecular Biology Unit, Experimental Medicine & Biotechnology Department, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cross-talk between coding RNAs and regulatory non-coding microRNAs, within human genome, has provided compelling evidence for the existence of flexible checkpoint control of T-Cell activation. The present study attempts to demonstrate that the interplay between miR-2909 and its effector KLF4 gene has the inherent capacity to regulate genes coding for CTLA4, CD28, CD40, CD134, PDL1, CD80, CD86, IL-6 and IL-10 within normal human peripheral blood mononuclear cells (PBMCs). Based upon these findings, we propose a pathway that links miR-2909 RNomics with the genes coding for immune checkpoint regulators required for the maintenance of immune homeostasis.

Indexed as

Antigens, CDB7-H1 AntigenHumansImmunologic FactorsKruppel-Like Factor 4Leukocytes, MononuclearMicroRNAsProgrammed Cell Death 1 ReceptorSignal TransductionAntigens, CDB7-H1 AntigenCD274 protein, humanImmunologic FactorsKLF4 protein, humanKruppel-Like Factor 4MicroRNAsMIRN2909 microRNA, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorCheckpoint regulationEctopic expressionHuman PBMCsKLF4MiR-2909

Identifiers

PMID29926320
OpenAlexW2809057340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.