Evidence map›Paper›PMID 29926317›Full record

SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018

The Efficacy of Antimicrobial-Coated Sutures for Preventing Incisional Surgical Site Infections in Digestive Surgery: a Systematic Review and Meta-analysis.

Motoi Uchino, Toru Mizuguchi, Hiroki Ohge, Seiji Haji, Junzo Shimizu, Yasuhiko Mohri, Chizuru Yamashita, Yuichi Kitagawa, Katsunori Suzuki, Motomu Kobayashi and 6 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Motoi UchinoDepartment of Inflammatory Bowel Disease, Hyogo College of Medicine, 1-1, Mukogawacho, Nishinomiya, Japan. uchino2s@hyo-med.ac.jp.ORCID 0000-0002-2934-1680
Toru MizuguchiDepartment of Surgery, Surgical Oncology & Science, Sapporo Medical University, Sapporo, Japan.
Hiroki OhgeDepartment of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan.
Seiji HajiDepartment of Surgery, Takatsuki General Hospital, Osaka, Japan.
Junzo ShimizuDepartment of Surgery, Osaka Rosai Hospital, Osaka, Japan.
Yasuhiko MohriDepartment of Surgery, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Chizuru YamashitaDepartment of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Yuichi KitagawaDepartment of Infection Control, National Center for Geriatrics and Gerontology, Obu, Japan.
Katsunori SuzukiDivision of Infection Control and Prevention, University of Occupational and Environmental Health, Fukuoka, Japan.
Motomu KobayashiDepartment of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan.
Masahiro KobayashiKitasato University School of Pharmacy, Tokyo, Japan.
Fumie SakamotoInfection Control Manager, QI Center, St. Luke's International University, Tokyo, Japan.
Masahiro YoshidaHemodialysis and Surgery, International University of Health and Welfare Ichikawa Hospital, Ichikawa, Japan.
Toshihiko MayumiDepartment of Emergency Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
Koichi HirataDepartment of Surgery, JR Sapporo Hospital, Sapporo, Japan.
SSI Prevention Guideline Committee of the Japan Society for Surgical Infection

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntimicrobial-coated sutures have recently become well known for preventing surgical site infections (SSIs). However, the evidence and recommendations from some organizations remain controversial. Therefore, we conducted a systematic review and meta-analysis to analyze the efficacy of antimicrobial-coated sutures for preventing SSIs in digestive surgery.

methodsWe performed a systematic review of literature published from 2000 to 2017 (registered on PROSPERO, No. CRD42017076780). We included studies defined as randomized controlled trials (RCTs) and observational studies (OBSs) for the prevention of SSIs and the reduction in hospital stay length associated with digestive surgery.

resultsIn the 10 RCTs, the incidence rates of incisional SSIs were 160/1798 (8.9%) with coated sutures and 205/1690 (12.1%) with non-coated sutures. Overall, antimicrobial-coated sutures were superior for reducing the incidence of incisional SSI (risk ratio (RR) 0.67, 95% confidence intervals (CI) 0.48-0.94, p = 0.02) in RCTs for digestive surgery with the mixed wound class and surgeries limited to a clean-contaminated wound (RR 0.66, 95% CI 0.44-0.98, p = 0.04). A superior effect of antimicrobial-coated sutures was found in 9 RCTs that involved only colorectal surgeries (RR 0.69, 95% CI 0.49-0.98, p = 0.04). The mean hospital stay length was similar with coated or uncoated sutures in 5 RCTs involving colorectal surgery (mean difference (MD) - 5.00, 95% CI 16.68-6.69, p = 0.4).

conclusionAntimicrobial-coated sutures are significantly more efficacious for preventing SSIs during digestive and colorectal surgery, even when restricted to clean-contaminated wounds. However, the hospital stay length was not affected.

Indexed as

SuturesAnti-Infective Agents, LocalDigestive System Surgical ProceduresHumansLength of StayObservational Studies as TopicRandomized Controlled Trials as TopicSurgical Wound InfectionTriclosanAnti-Infective Agents, LocalTriclosanAntimicrobial-coated sutureColorectal surgeryDigestive surgerySurgical site infection

Identifiers

PMID29926317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.