Evidence map›Paper›PMID 29926243›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2019

Silver-coated megaprostheses in the proximal femur in patients with sarcoma.

Arne Streitbuerger, Marcel P Henrichs, Gregor Hauschild, Markus Nottrott, Wiebke Guder, Jendrik Hardes

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Arne StreitbuergerDepartment of Orthopedics and Tumor Orthopedics, Münster University Hospital, Münster, Germany.
Marcel P HenrichsDepartment of Orthopedics, Paracelsus Clinic, Osnabrück, Germany.
Gregor HauschildDepartment of Orthopedics and Tumor Orthopedics, Münster University Hospital, Münster, Germany.
Markus NottrottDepartment of Orthopedics and Tumor Orthopedics, Münster University Hospital, Münster, Germany.
Wiebke GuderDepartment of Orthopedics and Tumor Orthopedics, Münster University Hospital, Münster, Germany.
Jendrik HardesDepartment of Orthopedics and Tumor Orthopedics, Münster University Hospital, Münster, Germany. jendrik.hardes@uk-essen.de.
Essen University Hospital · DEUniversity Hospital Münster · DEParacelsus-Kliniken · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProximal femur replacements in patients with sarcoma are associated with high rates of infection. This study is the largest one comparing infection rates with titanium versus silver-coated megaprostheses in sarcoma patients.

methodsInfection rates were assessed in 99 patients with proximal femur sarcoma who underwent placement of a titanium (n = 35) or silver-coated (n = 64) megaprosthesis. Treatments administered for infection were also analyzed.

resultsInfections occurred in 14.3% of patients in the titanium group, in comparison with 9.4% of those in the silver group, when the development of infection was the primary end point. The 5- and 10-year event-free survival rates for the prosthesis relative to the parameter of infection were 90% in the silver group and 83% in the titanium group. The overall infection rates were 10.9% in the silver group and 20% in the titanium group. Two patients each in the silver and titanium groups ultimately had to undergo amputation. The need for two-stage prosthesis exchanges (57.1% in the titanium group) declined to 14.3% in the silver group.

conclusionUsing a silver-coated proximal femoral replacement nearly halved the overall infection rate. When infections occurred, it was usually possible to avoid two-stage prosthesis exchanges in the silver group.

Indexed as

AdolescentAdultAgedAged, 80 and overBone NeoplasmsChildChild, PreschoolFemurHumansMiddle AgedProstheses and ImplantsProsthesis DesignProsthesis-Related InfectionsSarcomaSilverSoft Tissue NeoplasmsSilverTitaniumBone neoplasmsImplantationProsthesis-related infectionsProximal femurSarcomaSilver

Identifiers

PMID29926243
OpenAlexW2809359493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.