ArticleThe European physical journal. E, Soft matter2018
Translocation of polyampholytes and intrinsically disordered proteins
Article in The European physical journal. E, Soft matter, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Manifold of Polyampholyte Necklaces: From Charge Migration to Hierarchical Structure.Macromolecules · 2025Article
- Review
- Anti-polyelectrolyte and polyelectrolyte effects on conformations of polyzwitterionic chains in dilute aqueous solutions.PNAS nexus · 2023Article
- Translocation, Rejection and Trapping of Polyampholytes.Polymers · 2022Article
- Sequence Blockiness Controls the Structure of Polyampholyte Necklaces.ACS macro letters · 2021Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyampholytes are polymers carrying electrical charges of both signs along their backbone. We consider synthetic polyampholytes with a quenched random charge sequence and intrinsically disordered proteins, which have a well-defined charge sequence and behave like polyampholytes in the denaturated state. We study their translocation driven by an electric field through a pore. The role of disorder along the charge sequence of synthetic polyampholytes is analyzed. We show how disorder slows down the translocation dynamics. For intrinsically disordered proteins, the translocation vs. rejection rates by the pore depends on which end is engaged in the translocation channel. We discuss the rejection time, the blockade time distributions and the translocation speed for the charge sequence of two specific intrinsically disordered proteins differing in length and structure.
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