Evidence map›Paper›PMID 29926199›Full record

ArticleMikrochimica acta2018

Ultrasensitive detection of heparin by exploiting the silver nanoparticle-enhanced fluorescence of graphitic carbon nitride (g-C

Qiao Cheng, Yu He, Yili Ge, Jiangang Zhou, Gongwu Song

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Heptazine-BasedFrontiers in chemistry · 2021
    Review
  6. Techniques for Detection of Clinical Used Heparins.International journal of analytical chemistry · 2021
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Qiao ChengHubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China.
Yu HeHubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China. heyu@hubu.edu.cn.ORCID 0000-0002-8068-5825
Yili GeHubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China.
Jiangang ZhouHubei Province Key Laboratory of Regional Development and Environment Response, Wuhan, 430062, China.
Gongwu SongHubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China.
Hubei University · CNMinistry of Education · IR

Funding

National Natural Science Foundation of China 21707300Wuhan Youth Science and technology plan 2016070204010133
6 · The paper itself

Abstract

A composite (Ag-g-CNQDs) was prepared from graphitic carbon nitride quantum dots and silver nanoparticles by water phase synthesis. Aided by metal-enhanced fluorescence, the composite exhibits excitation-dependent red emission with a peak at 600 nm with a quantum yield of 21%. If the composite is coated with polyethylenimine (PEI) to form the Ag-g-CNQD/PEI complexe, fluorescence is strongly reduced. Upon addition of heparin, the fluorescence of the system is enhanced because PEI has a higher affinity for heparin than Ag-g-CNQDs. The effect was used to design a fluorometric  assay for heparin. The emission at 600 nm increases linearly in the 0.025 to 2.5 μM heparin concentration range, with a 8.2 nM limit of detection. Graphical abstract Schematic illustration for fabricating a composite consisting of silver nanoparticles and graphitic carbon nitride quantum dots (Ag-g-CNQDs). Its red fluorescence is weak in presence of polyethyleneimine but restored on addition of heparin. This forms the basis for a new method for heparin detection.

Indexed as

Limit of DetectionGraphiteHeparinHumansHydrogen BondingMetal NanoparticlesModels, MolecularMolecular ConformationNitrilesPolyethyleneimineQuantum DotsSilverSpectroscopy, Fourier Transform InfraredStatic ElectricitycyanogenGraphiteHeparinNitrilesPolyethyleneimineSilverg-CNQDsHeparinMetal-enhanced fluorescenceRed emissionSilver nanoparticles

Identifiers

PMID29926199
OpenAlexW2809534408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.