Evidence map›Paper›PMID 29926175›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018

To do or not to do: salvage management for hypopharyngeal cancer after chemoradiation therapy.

Pei-Hsin Chu, Ngan-Ming Tsang, Li-Ang Lee, Chun-Ta Liao, Tuan-Jen Fang

Abstract read
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Functional and quality-of-life outcomes following salvage surgery for recurrent squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Pooled it
  2. Article
  3. Lateral conservative approach for recurrent/persistent hypopharyngeal carcinoma: a case series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020
    Article
  4. Article
4 · The record

Corrections and comments

  • Commented on by
    2018
5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pei-Hsin ChuDepartment of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5, Fu-Shin Street, Kweishan 333, Taoyuan, Taiwan.
Ngan-Ming TsangChang Gung University College of Medicine, Taoyuan, Taiwan.
Li-Ang LeeDepartment of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5, Fu-Shin Street, Kweishan 333, Taoyuan, Taiwan.
Chun-Ta LiaoDepartment of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5, Fu-Shin Street, Kweishan 333, Taoyuan, Taiwan.
Tuan-Jen FangDepartment of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5, Fu-Shin Street, Kweishan 333, Taoyuan, Taiwan. fang3109@cgmh.org.tw.ORCID http://orcid.org/0000-0002-7805-3458
Chang Gung University · TW

Funding

Chang Gung Medical Foundation Grant CMRPG 3G1241
6 · The paper itself

Abstract

purposesThe management of recurrent hypopharyngeal cancer after primary curative-intent radiation or chemoradiation therapy is inconclusive. The benefit of salvage surgery may be reduced by its high complication rate. The improvement of medical care modalities may change the survival after management for loco-reginal recurrences. The present study aims to determine the role of salvage surgery.

methodsFrom December 2007 to November 2013, 46 patients with recurrent hypopharyngeal squamous cell carcinoma (HPSCC) after radiation or chemoradiation therapy and without double cancers were recruited. Two year loco-regional failure and overall survival were analyzed and compared between failure patterns.

resultsFive-year survival was 24% in patients after loco-regional recurrences. Those who received salvage surgery for loco-regional recurrences had significantly better survival (P < 0.001). Among patients with salvage surgery, 2-year overall survival was significantly higher in recurrent (n = 11) than persistent (n = 24) disease (90 vs 38%, P = 0.006).

conclusionsSalvage surgery provides better oncologic outcomes in patients with HPSCC, especially for patients with recurrences after 6 months since completion of primary radiation or chemoradiation. The present data of outcomes can be provided for pretreatment consultation for loco-regional recurrent hypopharyngeal cancers.

Indexed as

Salvage TherapyAdultAgedCarcinoma, Squamous CellChemoradiotherapyFemaleHumansHypopharyngeal NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeChemoradiation therapyRadiation therapyRecurrent hypopharyngeal cancerSalvage surgerySurvival

Identifiers

PMID29926175
OpenAlexW2808953277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.