Evidence map›Paper›PMID 29926136›Full record

ArticleUrolithiasis2019

Association between vitamin D receptor gene polymorphisms and idiopathic hypocitraturia in a Chinese Bai population.

Kangjian Li, Yuhui Luo, Yin Mo, Jihong Shen, Xiaodong Liu, Hao Li

Abstract read
PubMed Publisher
In one paragraph

Article in Urolithiasis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kangjian LiDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, China.
Yuhui LuoDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, China.
Yin MoDepartment of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, China. 1559272743@qq.com.
Jihong ShenDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, China.
Xiaodong LiuDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, China.
Hao LiDepartment of Urology, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, China. lihao5935252@163.com.ORCID http://orcid.org/0000-0002-4081-2455
Kunming Medical University · CN

Funding

Doctoral Scientific Research Fund of the First Affiliated Hospital of Kunming Medical University 2015BS026Doctoral Scientific Research Fund of the First Affiliated Hospital of Kunming Medical University 2017BS016National Natural Science Foundation of China 81460141Science and Technology Department of Yunnan Province Uniting Kunming Medical University Specialized Foundation 2013FB134Science and Technology Department of Yunnan Province Uniting Kunming Medical University Specialized Foundation 2017FE467(-042)Science and Technology Department of Yunnan Province Uniting Kunming Medical University Specialized Foundation 2017FE468(-029)The scientific research funding of Yunnan Provincial Department of Education 2018JS208
6 · The paper itself

Abstract

Idiopathic hypocitraturia (IH) is a risk factor for urolithiasis. IH is associated with vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) in a Chinese Han population. However, this association between VDR SNPs and IH has not been recapitulated in a Chinese Bai population. The aim of this study is to investigate the association between VDR SNPs and IH in a Chinese Bai population. A total of 320 participants comprising of 200 Chinese Bai patients with IH and 120 Chinese Bai control participants with normal urinary citrate level were enrolled for this study. The VDR SNPs rs7975232, rs2228570, rs731236 and rs1544410 were detected by Sanger sequencing, and the association between these SNPs and the presence of IH in the Chinese Bai population was analyzed. The prevalence of VDR SNPs rs7975232 allele A and rs2228570 genotype TT was significantly higher in patients than in controls (p < 0.0125, after Bonferroni correction). The haplotype TCGC was a protective factor in the Chinese Bai population who otherwise might suffer from IH, while the haplotype TTGA was a risk factor. VDR SNPs rs731236 and rs1544410 have a linkage disequilibrium value of 0.811. VDR SNPs rs7975232, rs2228570, and haplotypes TCGC, TTGA are associated with IH in a Chinese Bai population.

Indexed as

Genetic Predisposition to DiseaseAdultAsian PeopleCase-Control StudiesChinaCitric AcidFemaleGenetic Association StudiesHaplotypesHumansMaleMiddle AgedNephrolithiasisPolymorphism, Single NucleotideReceptors, CalcitriolRisk FactorsCitric AcidReceptors, CalcitriolVDR protein, humanChinese Bai populationIdiopathic hypocitraturia (IH)Sanger sequencingSingle nucleotide polymorphism (SNP)Vitamin D receptor (VDR)

Identifiers

PMID29926136
OpenAlexW2809093067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.