ArticleNature immunology2018
The E3 ligases Itch and WWP2 cooperate to limit T
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In one paragraph
Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TNature communications · 2026Article
- Enhanced WWP2 Exacerbates Podocyte Injury in Lupus Nephritis through Monoubiquitylating H2A at K119.International journal of biological sciences · 2026Article
- The role of HECT-type E3 ubiquitin ligases in inflammation.Frontiers in immunology · 2026Review
- WWP2 in immune surveillance and antigen presentation: context-dependent roles in B cells, T cells, and tumor immune escape.Frontiers in immunology · 2026Review
- PARG inhibition suppresses breast cancer progression and potentiates immunoresponse through MTDH degradation mediated by E3 ligase ITCH-dependent ubiquitination.NPJ breast cancer · 2025Article
- WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis.Journal of advanced research · 2025Article
- A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.The EMBO journal · 2025Article
- Exploring the prevalence of atopic disease among adult cancer survivors: insights from the 2021 NHIS.PloS one · 2025Article
- The role of ubiquitination in health and disease.MedComm · 2024Review
- A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.bioRxiv : the preprint server for biology · 2023Article
- T helper 2 cells in asthma.The Journal of experimental medicine · 2023Review
- Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.Cardiovascular diabetology · 2023Article
- E2Computers in biology and medicine · 2022Article
- HIV-1 Vif suppresses antiviral immunity by targeting STING.Cellular & molecular immunology · 2022Article
- Review
- The Ubiquitin-Proteasome System in Immune Cells.Biomolecules · 2021Review
- Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for Treatment.Journal of immunology research · 2021Observational
- ITCH as a potential therapeutic target in human cancers.Seminars in cancer biology · 2020Review
- The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.Cell host & microbe · 2020Article
- Itch regulation of innate and adaptive immune responses in mice and humans.Journal of leukocyte biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Daisuke AkiInstitute for Immunology, Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.
Hui LiInstitute for Immunology, Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.
Wen ZhangInstitute for Immunology, Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.
Mingke ZhengInstitute for Immunology, Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.
Chris EllyLa Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Jee H LeeLa Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Weiguo ZouShanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-2516-0302
Yun-Cai LiuInstitute for Immunology, Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China. yuncai_liu@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-0996-7109
La Jolla Institute for Immunology · USCenter for Life Sciences · CNChinese Academy of Sciences · CN
Funding
Regulation of innate lymphoid cells in inflammationR01AI123398 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2016 to 2020
$2.2MFACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514kUbiquitination in Immune ToleranceR21AI126487 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LIU, YUN-CAI · 2018 to 2019
$495kDeubiquitination in Immune RegulationR21AI122258 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LIU, YUN-CAI · 2016 to 2017
$487kRegulation of Lung Inflammation by Protein UbiquitinationR56AI137017 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LIU, YUN-CAI · 2018 to 2018
$450kDeubiquitination in Immune RegulationR56AI132765 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LIU, YUN-CAI · 2018 to 2018
$270kNIAID NIH HHS R01 AI123398NIAID NIH HHS R21 AI122258NIAID NIH HHS R21 AI126487NIAID NIH HHS R56 AI132765NIAID NIH HHS R56 AI137017
Abstract
The mechanisms by which the sensitivity of naive CD4
Indexed as
AnimalsAutoimmunityCell DifferentiationHumansInflammationJurkat CellsLymphocyte Specific Protein Tyrosine Kinase p56(lck)MiceMice, KnockoutProtein Tyrosine Phosphatase, Non-Receptor Type 6Receptors, Antigen, T-CellRepressor ProteinsSignal TransductionTh2 CellsUbiquitinationUbiquitin-Protein LigasesITCH protein, humanItch protein, mouseLymphocyte Specific Protein Tyrosine Kinase p56(lck)Protein Tyrosine Phosphatase, Non-Receptor Type 6Receptors, Antigen, T-CellRepressor ProteinsUbiquitin-Protein LigasesWWP2 protein, humanWwp2 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.