ArticleNature immunology2018
Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.
Erratum issued Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02100397 (Development of a Human Model of Salmonella Enterica Serovar Paratyphi A Challenge in Healthy Adult Volunteers), which is not on this map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Human Model of Salmonella Enterica Serovar Paratyphi A Challenge in Healthy Adult Volunteers
Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model.PLoS neglected tropical diseases · 2020Trial
- The challenge and promise of studying human antigen-specific T cells.Nature reviews. Immunology · 2026Review
- Immunogenomic landscape of the T cell repertoire after human lung transplantation and its clinical relevance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19.Frontiers in immunology · 2026Article
- Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.The Journal of experimental medicine · 2025Article
- Self-supervised learning of T cell receptor sequences exposes core properties for T cell membership.Science advances · 2024Article
- Dynamic establishment of recipient resident memory T cell repertoire after human intestinal transplantation.EBioMedicine · 2024Article
- A systematic analysis of the human immune response to Plasmodium vivax.The Journal of clinical investigation · 2023Article
- Decitabine increases neoantigen and cancer testis antigen expression to enhance T-cell-mediated toxicity against glioblastoma.Neuro-oncology · 2022Article
- Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution.Mucosal immunology · 2022Review
- Controlled human infectious models, a path forward in uncovering immunological correlates of protection: Lessons from enteric fevers studies.Frontiers in microbiology · 2022Review
- Broadly reactive human CD4European journal of immunology · 2021Article
- Remembering Enzo Cerundolo.Molecular immunology · 2021Article
- Progress and applications of mass cytometry in sketching immune landscapes.Clinical and translational medicine · 2020Review
- Evasion of MAIT cell recognition by the AfricanProceedings of the National Academy of Sciences of the United States of America · 2020Article
- An overview of immunoinformatics approaches and databases linking T cell receptor repertoires to their antigen specificity.Immunogenetics · 2020Review
- Differential functional patterns of memory CD4Vaccine · 2020Article
- HumanClinical & translational immunology · 2020Article
- Using a Systems Biology Approach To Study Host-Pathogen Interactions.Microbiology spectrum · 2019Review
- Effect of the live oral attenuated typhoid vaccine, Ty21a, on systemic and terminal ileum mucosal CD4+ T memory responses in humans.International immunology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
30 authors at 7 institutions in 6 countries.
Giorgio NapolitaniMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. giorgio.napolitani@imm.ox.ac.uk.ORCID http://orcid.org/0000-0002-3605-6394
Prathiba KurupatiMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Karen Wei Weng TengSingapore Immunology Network, Agency of Science, Technology and Research, Singapore, Singapore.
Malick M GibaniDepartment of Paediatrics, Oxford Vaccine Group, University of Oxford and NIHR Oxford Biomedical Research Centre, Oxford, UK.
Margarida ReiMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Anna AulicinoMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Lorena Preciado-LlanesMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Michael Thomas WongSingapore Immunology Network, Agency of Science, Technology and Research, Singapore, Singapore.
Etienne BechtSingapore Immunology Network, Agency of Science, Technology and Research, Singapore, Singapore.
Lauren HowsonMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3522-4533
Paola de HaasMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Mariolina SalioMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4821-3801
Christoph J BlohmkeDepartment of Paediatrics, Oxford Vaccine Group, University of Oxford and NIHR Oxford Biomedical Research Centre, Oxford, UK.
Lars Rønn OlsenDepartment of Bio and Health Informatics, Technical University of Denmark, Copenhagen, Denmark.
David Miguel Susano PintoDepartment of Biochemistry, Micron Oxford, University of Oxford, Oxford, UK.
Laura ScifoMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Claire JonesDepartment of Paediatrics, Oxford Vaccine Group, University of Oxford and NIHR Oxford Biomedical Research Centre, Oxford, UK.
Hazel DobinsonDepartment of Paediatrics, Oxford Vaccine Group, University of Oxford and NIHR Oxford Biomedical Research Centre, Oxford, UK.
Danielle CampbellDepartment of Paediatrics, Oxford Vaccine Group, University of Oxford and NIHR Oxford Biomedical Research Centre, Oxford, UK.ORCID http://orcid.org/0000-0001-5794-8036
Helene B JuelDepartment of Paediatrics, Oxford Vaccine Group, University of Oxford and NIHR Oxford Biomedical Research Centre, Oxford, UK.
Helena Thomaides-BrearsDepartment of Paediatrics, Oxford Vaccine Group, University of Oxford and NIHR Oxford Biomedical Research Centre, Oxford, UK.
Derek PickardWellcome Trust Sanger Institute, Hinxton, UK.
Dirk BumannBiozentrum, University of Basel, Basel, Switzerland.
Stephen BakerHospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Gordon DouganWellcome Trust Sanger Institute, Hinxton, UK.
Alison SimmonsMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Melita A GordonInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Evan William NewellSingapore Immunology Network, Agency of Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2889-243X
Andrew J PollardDepartment of Paediatrics, Oxford Vaccine Group, University of Oxford and NIHR Oxford Biomedical Research Centre, Oxford, UK.
Vincenzo CerundoloMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
University of Oxford · GBSingapore Immunology Network · SGUniversity of Liverpool · GBWellcome Sanger Institute · GBOxford University Clinical Research Unit · VNTechnical University of Denmark · DKUniversity of Basel · CH
Funding
Department of Health NIHR-RP-R3-12-026Medical Research Council MC_UU_00008/1Medical Research Council MC_UU_00008/7Medical Research Council MC_UU_12010/7Medical Research Council MR/K021222/1
Abstract
To tackle the complexity of cross-reactive and pathogen-specific T cell responses against related Salmonella serovars, we used mass cytometry, unbiased single-cell cloning, live fluorescence barcoding, and T cell-receptor sequencing to reconstruct the Salmonella-specific repertoire of circulating effector CD4
Indexed as
ADP-ribosyl Cyclase 1AdultAntigens, BacterialCD4-Positive T-LymphocytesClone CellsHumansPhenotypeReceptors, CCR7Salmonella paratyphi ASalmonella typhiTyphoid FeverADP-ribosyl Cyclase 1Antigens, BacterialCCR7 protein, humanReceptors, CCR7
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02100397ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.