Evidence map›Paper›PMID 29925948›Full record

ArticleNature2018

Altered exocrine function can drive adipose wasting in early pancreatic cancer.

Laura V Danai, Ana Babic, Michael H Rosenthal, Emily A Dennstedt, Alexander Muir, Evan C Lien, Jared R Mayers, Karen Tai, Allison N Lau, Paul Jones-Sali and 19 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.

  1. Guideline
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  14. The Power of Drosophila in Modeling Cancer Cachexia.Advances in experimental medicine and biology · 2025
    Review
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 12 institutions in 2 countries.

Laura V Danai *Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ana Babic *Dana-Farber Cancer Institute, Boston, MA, USA.
Michael H RosenthalDana-Farber Cancer Institute, Boston, MA, USA.
Emily A DennstedtKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alexander MuirKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Evan C LienKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jared R MayersKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Karen TaiKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Allison N LauKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Paul Jones-SaliKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Carla M PradoDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Gloria M PetersenMayo Clinic, Rochester, MN, USA.
Naoki TakahashiMayo Clinic, Rochester, MN, USA.
Motokazu SugimotoMayo Clinic, Rochester, MN, USA.
Jen Jen YehDepartment of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nicole LopezUniversity of California San Diego School of Medicine, La Jolla, CA, USA.
Nabeel BardeesyMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Carlos Fernandez-Del CastilloMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Andrew S LissMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Albert C KoongMD Anderson, Department of Radiation Oncology, Houston, TX, USA.
Justin BuiStanford Cancer Institute, Stanford, CA, USA.
Chen YuanDana-Farber Cancer Institute, Boston, MA, USA.
Marisa W WelchDana-Farber Cancer Institute, Boston, MA, USA.
Lauren K BraisDana-Farber Cancer Institute, Boston, MA, USA.
Matthew H KulkeDana-Farber Cancer Institute, Boston, MA, USA.
Courtney DennisBroad Institute of MIT and Harvard University, Cambridge, MA, USA.
Clary B ClishBroad Institute of MIT and Harvard University, Cambridge, MA, USA.
Brian M WolpinDana-Farber Cancer Institute, Boston, MA, USA. bwolpin@partners.org.
Matthew G Vander HeidenKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu.
Massachusetts Institute of Technology · USDana-Farber Cancer Institute · USHarvard University · USMayo Clinic in Arizona · USMassachusetts General Hospital · USBoston Medical Center · USBroad Institute · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alberta · CAUniversity of California, Los Angeles · USUniversity of California, San Diego · USUniversity of North Carolina at Chapel Hill · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
The RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7M
PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Tissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI BASS, ADAM JOEL · 2007 to 2023
$33.2M
Tissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2018
$32.7M
Circulating Biomarker Consortium for Pancreatic Cancer Early DetectionU01CA210171 · NCI · DANA-FARBER CANCER INST · PI Michael H. Rosenthal, Brian Matthew Wolpin · 2016 to 2026
$8.7M
Regulation of glucose metabolism to allow tumor initiation and growthR01CA168653 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VANDER HEIDEN, MATTHEW G. · 2013 to 2019
$1.9M
Obesity and Pancreatic Cancer Progression and SurvivalK07CA222159 · NCI · DANA-FARBER CANCER INST · PI BABIC, ANA · 2018 to 2022
$747k
Understanding metabolic pathways that support redox homeostasis in cancerF32CA213810 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MUIR, ALEXANDER · 2017 to 2018
$112k
Understanding cell intrinsic and context dependent metabolic adaptations of cancer cellF32CA210421 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DANAI, LAURA VICTORIA · 2016 to 2017
$88k
Howard Hughes Medical InstituteNCI NIH HHS F32 CA210421NCI NIH HHS F32 CA213810NCI NIH HHS K07 CA222159NCI NIH HHS P01 CA117969NCI NIH HHS P30 CA014051NCI NIH HHS P50 CA102701NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA168653NCI NIH HHS U01 CA210171NIGMS NIH HHS T32 GM007287
6 · The paper itself

Abstract

Malignancy is accompanied by changes in the metabolism of both cells and the organism

Indexed as

Adipose TissueAnimalsBody CompositionDisease Models, AnimalDisease ProgressionExocrine Pancreatic InsufficiencyFemaleMaleMicePancreatic Neoplasms

Identifiers

PMID29925948
PMCPMC6112987
OpenAlexW2809397712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.