ArticleScientific reports2018
Isolation of cells from whole blood using shear-induced diffusion.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- In-Line Enrichment of Cancer Cells from Whole Blood by Cell Self-Organization in Acoustic Fields.Analytical chemistry · 2025Article
- Vortex sorting of rare particles/cells in microcavities: A review.Biomicrofluidics · 2024Review
- Recent advances in microfluidic cell separation to enable centrifugation-free, low extracorporeal volume leukapheresis in pediatric patients.Blood transfusion = Trasfusione del sangue · 2023Review
- Single Cell Analysis of Inertial Migration by Circulating Tumor Cells and Clusters.Micromachines · 2023Article
- Evolution of focused streams for viscoelastic flow in spiral microchannels.Microsystems & nanoengineering · 2023Article
- Advances in novel strategies for isolation, characterization, and analysis of CTCs and ctDNA.Therapeutic advances in medical oncology · 2023Review
- Laser transfer for circulating tumor cell isolation in liquid biopsy.International journal of bioprinting · 2023Article
- Direct separation and enumeration of CTCs in viscous blood based on co-flow microchannel with tunable shear rate: a proof-of-principle study.Analytical and bioanalytical chemistry · 2022Article
- Microfluidic techniques for isolation, formation, and characterization of circulating tumor cells and clusters.APL bioengineering · 2022Review
- Inertial focusing of particles and cells in the microfluidic labyrinth device: Role of sharp turns.Biomicrofluidics · 2022Article
- Microfluidic-Based Technologies for CTC Isolation: A Review of 10 Years of Intense Efforts towards Liquid Biopsy.International journal of molecular sciences · 2022Review
- Geometric structure design of passive label-free microfluidic systems for biological micro-object separation.Microsystems & nanoengineering · 2022Review
- New design to remove leukocytes from platelet-rich plasma (PRP) based on cell dimension rather than density.Bioactive materials · 2021Article
- Article
- Blood Plasma Self-Separation Technologies during the Self-Driven Flow in Microfluidic Platforms.Bioengineering (Basel, Switzerland) · 2021Review
- Rationale for Early Detection ofCancers · 2021Review
- Particle movement and fluid behavior visualization using an optically transparent 3D-printed micro-hydrocyclone.Biomicrofluidics · 2020Article
- Microfluidics Used as a Tool to Understand and Optimize Membrane Filtration Processes.Membranes · 2020Review
- Tandem microfluidic chip isolation of prostate and breast cancer cells from simulated liquid biopsies using CD71 as an affinity ligand.RSC advances · 2020Article
- Immunomagnetic separation of circulating tumor cells with microfluidic chips and their clinical applications.Biomicrofluidics · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extraction of cells of interest directly from whole blood is in high demand, yet extraordinary challenging due to the complex hemodynamics and hemorheology of the sample. Herein, we describe a new microfluidic platform that exploits the intrinsic complex properties of blood for continuous size-selective focusing and separation of cells directly from unprocessed whole blood. The novel system only requires routinely accessible saline solution to form a sandwiched fluid configuration and to initiate a strong effect of shear-induced diffusion of cells, which is coupled with fluid inertia for effective separation. Separations of beads and cells from whole blood have been successfully demonstrated with high efficiency (89.8%) at throughput of 6.75 mL/hr (10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.