ArticleScientific reports2018
Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- A Three-dimensional Analytical Framework for Retinal Microvasculature Reveals Layer-associated Vulnerability in Development and Neovascular Remodeling.bioRxiv : the preprint server for biology · 2026Article
- Comparison of optic nerve head and macular perfusion changes before and after the development of COVID-19.BMC ophthalmology · 2026Article
- Quantitative assessment of age-related retinal and choriocapillaris blood flow changes in a healthy Korean population using optical coherence tomography angiography.Scientific reports · 2026Article
- Clinical histopathology and pathogenesis of macular telangiectasia type 2.Progress in retinal and eye research · 2026Review
- Therapeutic approaches to diabetic macular edema assessed using optical coherence tomography and optical coherence tomography angiography.International journal of ophthalmology · 2026Review
- Retinal Vascular Density and Vessel Diameter in Sturge-Weber Syndrome Assessed by OCT-Angiography.Journal of clinical medicine · 2025Article
- Patterns of Structural Changes in the Fundus Measured by Optical Coherence Tomography Angiography as Potential Markers of Acute Mountain Sickness.Translational vision science & technology · 2023Article
- OCT-angiography based artificial intelligence-inferred fluorescein angiography for leakage detection in retina [Invited].Biomedical optics express · 2023Article
- Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA.Vision (Basel, Switzerland) · 2023Article
- Retinal arterial occlusive vasculitis after multiple intravitreal brolucizumab injections for diabetic macular edema.American journal of ophthalmology case reports · 2023Article
- Quantify retinal structure in high-altitude residents with and without high altitude polycythemia.BMC ophthalmology · 2023Article
- Innovative Macula Capillaries Plexuses Visualization with OCTA B-Scan Graph Representation: Transforming OCTA B-Scan into OCTA Graph Representation.Journal of multidisciplinary healthcare · 2023Article
- Optical Coherence Tomography and Optical Coherence Tomography Angiography: Essential Tools for Detecting Glaucoma and Disease Progression.Frontiers in ophthalmology · 2023Article
- The Impact of COVID-19 Infection on Macular Capillary Perfusion.Beyoglu eye journal · 2023Article
- Morphological Changes in the Foveal Avascular Zone after Panretinal Photocoagulation for Diabetic Retinopathy Using OCTA: A Study Focusing on Macular Ischemia.Medicina (Kaunas, Lithuania) · 2022Article
- Longitudinal characterization of retinal vasculature alterations with optical coherence tomography angiography in a mouse model of tauopathy.Experimental eye research · 2022Article
- Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behҫet's Disease Evaluated With Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2021Article
- Macular Vessel Density in Diabetic Retinopathy Patients: How Can We Accurately Measure and What Can It Tell Us?Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Foveal Remodeling of Retinal Microvasculature in Parkinson's Disease.Frontiers in neuroscience · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical coherence tomography angiography (OCTA) allows the retinal microvasculature to be visualized at various retinal depths. Previous studies introduced OCTA axial profile analysis and showed regional variations in the number and location of axially distinct vascular retinal plexuses. OCTA acquisition and processing approaches, however, vary in terms of their resulting transverse and axial resolutions, and especially the latter could potentially influence the profile analysis results. Our study imaged normal eyes using the Spectralis OCT2 with a full-spectrum, probabilistic OCTA algorithm, that, in marked contrast to split-spectrum approaches, preserves the original high OCT axial resolution also within the resulting OCTA signal. En face OCTA images are generally created by averaging flow signals over a finite axial depth window. However, we assessed regional OCTA signal profiles at each depth position at full axial resolution. All regions had two sharp vessel density peaks near the inner and outer boundaries of the inner nuclear layer, indicating separate intermediate and deep capillary plexuses. The superficial vascular plexus (SVP) separated into two distinct peaks within the ganglion cell layer in the parafoveal zone. The nasal, superior, and inferior perifovea had a deeper SVP peak that was shifted anteriorly compared to the parafoveal zone. Axial vascular density analysis with high-resolution, full spectrum OCTA thus allows healthy retinal vasculature to be precisely reconstructed and may be useful for clinically assessing retinal pathology.
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