ReviewNature reviews. Neurology2018
Neuroimmune disorders of the central nervous system in children in the molecular era.
Review in Nature reviews. Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis.Journal of clinical immunology · 2020Pooled it
- Cerebellar Involvement in Immune-Mediated Pediatric Acute Ataxia: Clinical Spectrum, MRI Findings, and Predictors of MOG Antibody Positivity.Cerebellum (London, England) · 2026Article
- Acute Disseminated Encephalomyelitis (ADEM): Current View into Etiopathogenesis and Clinical Features.Brain sciences · 2026Review
- Pediatric MOG-Ab-Associated Encephalitis: Supporting Early Recognition and Treatment.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Postacute Sequelae of SARS-CoV-2 in Children.Pediatrics · 2024Review
- Bickerstaff encephalitis in childhood: a review of 74 cases in the literature from 1951 to today.Frontiers in neurology · 2024Review
- Mechanisms of Cadmium Neurotoxicity.International journal of molecular sciences · 2023Review
- Therapeutic Implications of Some Natural Products for Neuroimmune Diseases: A Narrative of Clinical Studies Review.Evidence-based complementary and alternative medicine : eCAM · 2023Review
- Clinical features, investigations, and outcomes of pediatric limbic encephalitis: A multicenter study.Annals of clinical and translational neurology · 2022Observational
- Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.International journal of environmental research and public health · 2021Review
- Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study.The Lancet. Child & adolescent health · 2021Article
- Treatment patterns in pediatric patients with multiple sclerosis in Germany-a nationwide claim-based analysis.Therapeutic advances in neurological disorders · 2021Article
- Pediatric Inflammatory and Autoimmune Neurologic Disorders at a Tertiary Medical Center.Journal of child neurology · 2020Article
- Acute Disseminated Encephalomyelitis: Current Perspectives.Children (Basel, Switzerland) · 2020Review
- Narcolepsy risk and COVID-19.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Possible clinical role of MOG antibody testing in children presenting with acute neurological symptoms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children.Journal of clinical neurology (Seoul, Korea) · 2020Article
- Pediatric multiple sclerosis: from clinical basis to imaging spectrum and differential diagnosis.Pediatric radiology · 2020Review
- Clinical Perspective on Primary Angiitis of the Central Nervous System in Childhood (cPACNS).Frontiers in pediatrics · 2020Review
- Understanding auto-immune encephalitis in the ICU.Intensive care medicine · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
22 authors.
Funding
Abstract
Immune-mediated disorders of the CNS in children are a complex group of demyelinating, inflammatory, parainfectious and postinfectious disorders with heterogeneous pathobiological mechanisms and clinical manifestations, often associated with fundamental derangement in immune regulation. In this Review, we aim to provide an update on our knowledge of neuroimmune disorders and highlight areas of research that are priorities for improving clinical management. We outline the clinical features of neuroimmune disorders, the current approaches to their treatment and new approaches in development. We then consider the pathological features, including biomarkers, pathological mechanisms and genetics, and discuss the value of immune assays in clinical investigation and basic research. On the basis of current knowledge and techniques, we propose four research priorities: rigorous and consistent collection of core clinical data, cooperative investigation of treatments, development of biological assays and genetic studies. These priorities should help us to achieve the shared goal of precision medicine for neuroimmune disorders. However, multicentre research and the creation of clinical consortia for these rare disorders will be necessary, and we hope that this Review serves as a call to action that is timely given current exciting advances in neuroimmune therapeutics.
Indexed as
Identifiers
29925924What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.