Trial reportThe American journal of gastroenterology2018
A Randomized Controlled Trial of Opt-in Versus Opt-Out Colorectal Cancer Screening Outreach.
Abstract readComparative StudyPragmatic Clinical TrialRandomized Controlled Trial
In one paragraph
Trial report in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Behavioral Interventions Improve Mailed Colorectal Cancer Screening Among Overdue Patients in a Randomized Trial.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Trial
- Behaviorally Informed Text Messaging to Promote Colon Cancer Screening: A Quality Improvement Randomized Clinical Trial.JAMA network open · 2026Trial
- Nudges to Clinicians and Patients for Influenza Vaccines During Visits: The BE IMMUNE Randomized Clinical Trial.JAMA internal medicine · 2026Trial
- Effect of opt-in versus opt-out framing on trial recruitment: a study within a trial of the GAMEPAD randomized trial.American heart journal · 2026Trial
- Behavioral Economic Framing for Enrollment and Retention of Patients in Remote Blood Pressure Monitoring: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Postpartum Primary Care Engagement Using Default Scheduling and Tailored Messaging: A Randomized Clinical Trial.JAMA network open · 2024Trial
- A randomized trial of mailed outreach with behavioral economic interventions to improve liver cancer surveillance.Hepatology communications · 2024Trial
- Effect of Text Messaging and Behavioral Interventions on COVID-19 Vaccination Uptake: A Randomized Clinical Trial.JAMA network open · 2022Trial
- Text Messaging and Opt-out Mailed Outreach in Colorectal Cancer Screening: a Randomized Clinical Trial.Journal of general internal medicine · 2021Trial
- Effect of Opt-In vs Opt-Out Framing on Enrollment in a COVID-19 Surveillance Testing Program: The COVID SAFE Randomized Clinical Trial.JAMA network open · 2021Trial
- Behavioral interventions to improve population health outreach for hepatitis C screening: randomized clinical trial.BMJ (Clinical research ed.) · 2021Trial
- An RCT of Fecal Immunochemical Test Colorectal Cancer Screening in Veterans Without Recent Primary Care.American journal of preventive medicine · 2020Trial
- Effect of Sequential or Active Choice for Colorectal Cancer Screening Outreach: A Randomized Clinical Trial.JAMA network open · 2019Trial
- Implementation of electronic signposting to interventions that prevent cancer: A realist review.PLOS digital health · 2026Article
- A Telemedicine-Supported Home-Injection Model for Patients With Breast Cancer.JAMA network open · 2026Article
- Creating change through short-term pilots and rapid cycle testing: a case of cardiovascular risk reduction.BMJ open quality · 2026Article
- Messaging Informed by Behavioral Economics and Representativeness in Clinical Research Enrollment: Four Randomized Clinical Trials.JAMA network open · 2026Article
- How and Under What Conditions Do Patient Portals Improve Cancer Screening Completion: A Scoping Review.AJPM focus · 2026Review
- Potential Impact of the Medicare Prescription Payment Plan for Medicare Part D Beneficiaries With a Cancer Diagnosis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Shivan J MehtaDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Medicine Center for Health Care Innovation, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Leonard and Madlyn Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Tanya KhanDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Medicine Center for Health Care Innovation, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Leonard and Madlyn Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Carmen GuerraDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Medicine Center for Health Care Innovation, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Leonard and Madlyn Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Catherine ReitzDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Medicine Center for Health Care Innovation, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Leonard and Madlyn Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Timothy McAuliffeDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Medicine Center for Health Care Innovation, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Leonard and Madlyn Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Kevin G VolppDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Medicine Center for Health Care Innovation, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Leonard and Madlyn Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, USA.
David A AschDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Medicine Center for Health Care Innovation, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Leonard and Madlyn Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Chyke A DoubeniDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Medicine Center for Health Care Innovation, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Leonard and Madlyn Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Funding
Effectiveness of screening for colorectal cancer in average risk adults: Colonoscopy vs. FITR01CA213645 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DOUBENI, CHYKE ABADAMA · 2017 to 2021
$3.2MNCI NIH HHS R01 CA213645
Abstract
objectives
methods:
results: Patients randomized to opt-in agreed to participate 23.1% of the time, and only 2.5% of those in opt-out chose not to participate. FIT kits were mailed to 22.4% and 93% of patients in opt-in and opt-out arms, respectively. In intention-to-screen analysis, patients in the opt-out arm had a higher FIT completion rate (29.1%) than in the opt-in arm (9.6%) (absolute difference 19.5%; 95% confidence interval, 10.9-27.9%; P < .001). Results were similar in subgroup analysis of those sent initial messaging through the EHR portal (9.5% opt-in versus 37.5% in opt-out).
conclusions.
Indexed as
AgedColorectal NeoplasmsEarly Detection of CancerFemaleHumansImmunologic TestsMaleMass ScreeningMiddle AgedOccult BloodPatient Acceptance of Health CareRefusal to Participate
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.