Trial reportScientific reports2018
Guideline-based stepped and collaborative care for patients with depression in a cluster-randomised trial.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effectiveness of enhanced evidence-based care for depressive disorders: a meta-analysis of randomized controlled trials.Translational psychiatry · 2021Pooled it
- Cost-utility analysis of a collaborative and stepped care model in patients with mental disorders in German primary care (the COMET study).BMC psychiatry · 2025Trial
- Collaborative and Stepped Care for Mental Disorders: Results of a Cluster-Randomized Controlled Trial in Outpatient Care (The COMET Study).Deutsches Arzteblatt international · 2025Trial
- Matching depression management to severity prognosis in primary care: results of the Target-D randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Trial
- Cost-effectiveness of guideline-based stepped and collaborative care versus treatment as usual for patients with depression - a cluster-randomized trial.BMC psychiatry · 2020Trial
- A randomized noninferiority trial evaluating remotely-delivered stepped care for depression using internet cognitive behavioral therapy (CBT) and telephone CBT.Behaviour research and therapy · 2019Trial
- Effectiveness of stepped versus usual care for mental health service delivery: a systematic review and meta-analysis.International journal of mental health systems · 2026Article
- Effectiveness and implementation of an inpatient mental health care pathway at an epilepsy center: A prospective service evaluation.Epilepsia · 2026Article
- Beyond the medical file: A scoping review on patients' perspectives on depression treatment in primary care.PloS one · 2025Article
- Integrating psychiatry and family medicine in the management of somatic symptom disorders: Diagnosis, collaboration, and communication strategies.Journal of general and family medicine · 2025Review
- A Qualitative Investigation of Characteristics Impacting Clinical Decision-Making in Integrated Behavioral Health Care.The journal of behavioral health services & research · 2024Article
- A framework for precision "dosing" of mental healthcare services: algorithm development and clinical pilot.International journal of mental health systems · 2023Article
- Predicting treatment outcome in depression: an introduction into current concepts and challenges.European archives of psychiatry and clinical neuroscience · 2023Review
- Smartphone-delivered mental health care interventions for refugees: A systematic review of the literature.Global mental health (Cambridge, England) · 2023Review
- Effectiveness of a coordinated ambulatory care program for patients with mental disorders or multiple sclerosis: results of a prospective non-randomized controlled trial in South Germany.Frontiers in psychiatry · 2023Article
- Effectiveness and cost-effectiveness for the treatment of depressive symptoms in refugees and asylum seekers: A multi-centred randomized controlled trial.The Lancet regional health. Europe · 2022Article
- Telemental Health Collaborative Care Medication Management: Implementation and Outcomes.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2022Article
- Mental health professionals' perspective on a brief transdiagnostic psychological intervention for Afghan asylum seekers and refugees.European journal of psychotraumatology · 2022Article
- The Effects of Tai Chi on the Executive Functions and Physical Fitness in Middle-Aged Adults with Depression: A Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guidelines recommend stepped and collaborative care models (SCM) for depression. We aimed to evaluate the effectiveness of a complex guideline-based SCM for depressed patients. German primary care units were cluster-randomised into intervention (IG) or control group (CG) (3:1 ratio). Adult routine care patients with PHQ-9 ≥ 5 points could participate and received SCM in IG and treatment as usual (TAU) in CG. Primary outcome was change in PHQ-9 from baseline to 12 months (hypothesis: greater reduction in IG). A linear mixed model was calculated with group as fixed effect and practice as random effect, controlling for baseline PHQ-9 (intention-to-treat). 36 primary care units were randomised to IG and 13 to CG. 36 psychotherapists, 6 psychiatrists and 7 clinics participated in SCM. 737 patients were included (IG: n = 569 vs. CG: n = 168); data were available for 60% (IG) and 64% (CG) after 12 months. IG showed 2.4 points greater reduction [95% confidence interval (CI): -3.4 to -1.5, p < 0.001; Cohen's d = 0.45] (adjusted PHQ-9 mean change). Odds of response [odds ratio: 2.8; 95% CI: 1.6 to 4.7] and remission [odds ratio: 3.2; 95% CI: 1.58 to 6.26] were higher in IG. Guideline-based SCM can improve depression care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.