Evidence map›Paper›PMID 29925890›Full record

Trial reportNature communications2018

Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke.

A Biasiucci, R Leeb, I Iturrate, S Perdikis, A Al-Khodairy, T Corbet, A Schnider, T Schmidlin, H Zhang, M Bassolino and 4 more

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 268 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
268citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04353297 nacompletednot on this mapstarted 2021, after this paper: background citation

The PROMOTOER: a BCI -Based Intervention That Promotes Upper Limb Functional Motor Recovery. A Randomized Clinical Trial to Test Long-term Efficacy and to Identify Determinants of Response to Intervention in Subacute Stroke Patients

TypeinterventionalSponsorI.R.C.C.S. Fondazione Santa LuciaRan2021 to 2023Enrolled49ConditionsStroke, Motor DisordersArmsEEG-based BCI system for (hand) Motor Imagery training, Motor Imagery training
NCT06179745 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Study of Functional Electrical Stimulation With Assistive Support Driven by a Brain-Computer Interface on the Upper Limb Rehabilitation of Chronic Stroke Patients

TypeinterventionalSponsorUniversity of EssexRan2022 to 2025Enrolled32ConditionsStroke, Cerebrovascular, Hemiplegia and Hemiparesis, Stroke/Brain AttackArmsEEG-based brain-computer interface, Sham EEG-based brain-computer interface, Functional Electrical Stimulation, Active hand orthosis
NCT07610850 narecruitingnot on this mapstarted 2026, after this paper: background citation

Brain-controlled Spinal Cord Stimulation in Participants With Chronic Stroke for Lower and Upper Limb Rehabilitation

TypeinterventionalSponsorEcole Polytechnique Fédérale de LausanneRan2026 to 2032Enrolled3ConditionsStroke, HemiplegiaArmsARC-BSI Stroke system
3 · Its place in the literature

Who cites it

268 citing papers in PubMed, 16 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Trial
  18. Trial
  19. Trial
  20. Trial

208 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

A BiasiucciDefitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.ORCID http://orcid.org/0000-0001-9639-0370
R LeebDefitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
I IturrateDefitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
S PerdikisDefitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
A Al-KhodairySUVACare - Clinique Romande de Réadaptation, Sion, 1951, Switzerland.
T CorbetDefitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
A SchniderDivision of Neurorehabilitation, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, 1211, Switzerland.
T SchmidlinCenter for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Sion, 1951, Switzerland.
H ZhangDefitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
M BassolinoCenter for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Sion, 1951, Switzerland.
D ViceicCenter for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Sion, 1951, Switzerland.
P VuadensSUVACare - Clinique Romande de Réadaptation, Sion, 1951, Switzerland.
A G GuggisbergDivision of Neurorehabilitation, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, 1211, Switzerland.
J D R MillánDefitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland. jose.millan@epfl.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinically relevant, and lasting motor recovery in chronic stroke survivors more effectively than sham FES. Such recovery is associated to quantitative signatures of functional neuroplasticity. BCI patients exhibit a significant functional recovery after the intervention, which remains 6-12 months after the end of therapy. Electroencephalography analysis pinpoints significant differences in favor of the BCI group, mainly consisting in an increase in functional connectivity between motor areas in the affected hemisphere. This increase is significantly correlated with functional improvement. Results illustrate how a BCI-FES therapy can drive significant functional recovery and purposeful plasticity thanks to contingent activation of body natural efferent and afferent pathways.

Indexed as

Brain-Computer InterfacesArmBrainElectric Stimulation TherapyElectroencephalographyFemaleHumansMaleMiddle AgedMovementNeural PathwaysNeuronal PlasticityRecovery of FunctionStereotaxic TechniquesStrokeStroke Rehabilitation

Identifiers

PMID29925890
PMCPMC6010454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.