Trial reportScientific reports2018
Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Noninvasive Brain Stimulation over the Frontopolar Cortex Promotes Willingness to Exert Cognitive Effort in a Foraging-Like Sequential Choice Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- Effects of real-time visual feedback (D-WALL) on neuromuscular control in healthy adults: an fNIRS study.Frontiers in human neuroscience · 2026Article
- Stress and Inflammation Target Dorsolateral Prefrontal Cortex Function: Neural Mechanisms Underlying Weakened Cognitive Control.Biological psychiatry · 2025Review
- Neurocomputational model of compulsivity: deviating from an uncertain goal-directed system.Brain : a journal of neurology · 2024Article
- β-Glucan alleviates goal-directed behavioral deficits in mice infected with Toxoplasma gondii.Parasites & vectors · 2023Article
- Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior.Translational psychiatry · 2022Article
- Reinforcement-learning in fronto-striatal circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction.Biological psychiatry · 2021Article
- Effects of subclinical depression on prefrontal-striatal model-based and model-free learning.PLoS computational biology · 2021Article
- Why and how the brain weights contributions from a mixture of experts.Neuroscience and biobehavioral reviews · 2021Review
- Brain networks underlying vulnerability and resilience to drug addiction.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful adaptation to complex environments depends on the balance of at least two systems: a flexible but slow goal-directed system encoding action-outcome associations and an efficient but rigid habitual system linking responses to preceding stimuli. Recent evidence suggests that the inferolateral prefrontal cortex (ilPFC), a region well known to contribute to cognitive control processes, may play a crucial role in the balance of goal-directed and habitual responding. This evidence, however, comes mainly from correlational data and whether the ilPFC is indeed causally involved in the goal-directed vs. habitual control of behavior is unclear. Here, we used neuro-navigated theta-burst stimulation (TBS) to either inhibit or enhance right ilPFC functionality before participants completed an instrumental learning task designed to probe goal-directed vs. habitual behavioral control. TBS did not affect overall learning performance. However, participants that had received inhibitory TBS were less able to adapt their behavior to altered task demands, indicating a shift from goal-directed towards more habitual control of behavior. Sham or excitatory TMS groups showed no such effect and were comparable in their performance to an unstimulated control group. Our findings indicate a causal role of the ilPFC in the balance of goal-directed vs. habitual control of behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.