Evidence map›Paper›PMID 29925884›Full record

ArticleScientific reports2018

Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study.

Donghao Zhou, Bo Xi, Min Zhao, Liang Wang, Sreenivas P Veeranki

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04451876 (Social Media Use ,Online Health Information Seeking and Knowledge on Hypertension Among Undergraduate Students of Faculty of Medicine and Health Sciences), which is not on this map. Cited by 174 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04451876 completednot on this mapstarted 2020, after this paper: background citation

Social Media Use ,Online Health Information Seeking and Knowledge on Hypertension Among Undergraduate Students of Faculty of Medicine and Health Sciences (FMHS), Universiti Putra Malaysia (UPM)

TypeobservationalSponsorUniversiti Putra MalaysiaRan2020 to 2020Enrolled286ConditionsHypertension, Knowledge, Attitudes, Practice, Social Behavior
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  16. Catheter-based ultrasound renal denervation in patients with resistant hypertension: the randomized, controlled REQUIRE trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Donghao ZhouDepartment of Endocrinology, Linyi People's Hospital, 276003, Linyi, China.
Bo XiDepartment of Epidemiology, School of Public Health, Shandong University, Jinan, China. xibo2007@126.com.
Min ZhaoDepartment of Nutrition and Food Hygiene, School of Public Health, Shandong University, Jinan, China.
Liang WangDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee, USA.
Sreenivas P VeerankiDepartment of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical trials had provided evidence for the benefit effect of antihypertensive treatments in preventing future cardiovascular disease (CVD) events; however, the association between hypertension, whether treated/untreated or controlled/uncontrolled and risk of mortality in US population has been poorly understood. A total of 13,947 US adults aged ≥18 years enrolled in the Third National Health and Nutrition Examination Survey (1988-1994) were used to conduct this study. Mortality outcome events included all-cause, CVD-specific, heart disease-specific and cerebrovascular disease-specific deaths, which were obtained from linked 2011 National Death Index (NDI) files. During a median follow-up of 19.1 years, there were 3,550 all-cause deaths, including 1,027 CVD deaths. Compared with normotensives, treated but uncontrolled hypertensive patients were at higher risk of all-cause (HR = 1.62, 95%CI = 1.35-1.95), CVD-specific (HR = 2.23, 95%CI = 1.66-2.99), heart disease-specific (HR = 2.19, 95%CI = 1.57-3.05) and cerebrovascular disease-specific (HR = 3.01, 95%CI = 1.91-4.73) mortality. Additionally, untreated hypertensive patients had increased risk of all-cause (HR = 1.40, 95%CI = 1.21-1.62), CVD-specific (HR = 1.77, 95%CI = 1.34-2.35), heart disease-specific (HR = 1.69, 95%CI = 1.23-2.32) and cerebrovascular disease-specific death (HR = 2.53, 95%CI = 1.52-4.23). No significant differences were identified between normotensives, and treated and controlled hypertensives (all p > 0.05). Our study findings emphasize the benefit of secondary prevention in hypertensive patients and primary prevention in general population to prevent risk of mortality later in life.

Indexed as

AdolescentAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureCardiovascular DiseasesFemaleHumansHypertensionMaleMiddle AgedNutrition SurveysSurveys and QuestionnairesYoung AdultAntihypertensive Agents

Identifiers

PMID29925884
PMCPMC6010458

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.