Evidence map›Paper›PMID 29925843›Full record

ArticleNature communications2018

Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease.

Lark L Coffey, Rebekah I Keesler, Patricia A Pesavento, Kevin Woolard, Anil Singapuri, Jennifer Watanabe, Christina Cruzen, Kari L Christe, Jodie Usachenko, JoAnn Yee and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Zika Virus Neuropathogenesis-Research and Understanding.Pathogens (Basel, Switzerland) · 2024
    Review
  14. Article
  15. Nonhuman primate models of pediatric viral diseases.Frontiers in cellular and infection microbiology · 2024
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Lark L CoffeyDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA, 95616, USA. lcoffey@ucdavis.edu.ORCID http://orcid.org/0000-0002-0718-5146
Rebekah I KeeslerCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Patricia A PesaventoDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Kevin WoolardDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Anil SingapuriDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Jennifer WatanabeCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Christina CruzenCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Kari L ChristeCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Jodie UsachenkoCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
JoAnn YeeCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Victoria A HengCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Eliza Bliss-MoreauCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
J Rachel ReaderCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.ORCID http://orcid.org/0000-0003-3864-6731
Wilhelm von MorgenlandCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Anne M GibbonsCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Kenneth JacksonDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Amir ArdeshirCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.ORCID http://orcid.org/0000-0002-4330-4659
Holly HeimsathDuke Human Vaccine Institute, Duke University Medical Center, 103020, 2 Genome Court MSRBII, Durham, NC, 27710, USA.
Sallie PermarDuke Human Vaccine Institute, Duke University Medical Center, 103020, 2 Genome Court MSRBII, Durham, NC, 27710, USA.
Paranthaman SenthamaraikannanDivision of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.ORCID http://orcid.org/0000-0002-3333-3720
Pietro PresicceDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA.
Suhas G KallapurDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA.
Jeffrey M LinnenGrifols Diagnostic Solutions, Inc., 10808 Willow Court, San Diego, CA, 92127, USA.
Kui GaoGrifols Diagnostic Solutions, Inc., 10808 Willow Court, San Diego, CA, 92127, USA.
Robert OrrOffice of Counterterrorism and Emerging Threats, Office of the Chief Scientist, Food and Drug Administration, 25 New Hampshire Avenue, Silver Spring, MD, 20903, USA.
Tracy MacGillOffice of Counterterrorism and Emerging Threats, Office of the Chief Scientist, Food and Drug Administration, 25 New Hampshire Avenue, Silver Spring, MD, 20903, USA.
Michelle McClureOffice of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20903, USA.
Richard McFarlandThe Advanced Regenerative Manufacturing Institute, 400 Commercial Street, Manchester, NH, 03101, USA.
John H MorrisonCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Koen K A Van RompayCalifornia National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA. kkvanrompay@ucdavis.edu.ORCID http://orcid.org/0000-0002-7375-1337

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Development of a nonhuman primate model of fetal Zika virus infection and diseaseR21AI129479 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VAN ROMPAY, KOEN K · 2017 to 2018
$1.9M
NIAID NIH HHS R21 AI129479NIH HHS P51 OD011107UC | UC Davis | California National Primate Research Center (CNPRC) P51OD011107
6 · The paper itself

Abstract

Zika virus (ZIKV) infection of pregnant women can cause fetal microcephaly and other neurologic defects. We describe the development of a non-human primate model to better understand fetal pathogenesis. To reliably induce fetal infection at defined times, four pregnant rhesus macaques are inoculated intravenously and intraamniotically with ZIKV at gestational day (GD) 41, 50, 64, or 90, corresponding to first and second trimester of gestation. The GD41-inoculated animal, experiencing fetal death 7 days later, has high virus levels in fetal and placental tissues, implicating ZIKV as cause of death. The other three fetuses are carried to near term and euthanized; while none display gross microcephaly, all show ZIKV RNA in many tissues, especially in the brain, which exhibits calcifications and reduced neural precursor cells. Given that this model consistently recapitulates neurologic defects of human congenital Zika syndrome, it is highly relevant to unravel determinants of fetal neuropathogenesis and to explore interventions.

Indexed as

Disease Models, AnimalMacaca mulattaAnimalsBrainFemaleFetal DiseasesFetusHumansMaleNervous System DiseasesPregnancyPregnancy Complications, InfectiousRNA, ViralZika VirusZika Virus InfectionRNA, Viral

Identifiers

PMID29925843
PMCPMC6010452

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.