ArticleScientific reports2018
The relationship between metabolic syndrome and asthma in the elderly.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Associations between metabolic syndrome and allergic diseases a nationwide study in Korea and literature review.Scientific reports · 2026Article
- Association between platelet/high-density lipoprotein cholesterol ratio and blood eosinophil counts in American adults with asthma: a population-based study.Lipids in health and disease · 2025Article
- Asthma as a Modifiable Risk Factor for Dementia and Neurodegeneration: A Systematic Review.Cureus · 2025Review
- The impact of high-IgE levels on metabolome and microbiome in experimental allergic enteritis.Allergy · 2024Article
- Association between asthma, obesity, and metabolic syndrome in adolescents and young adults.The Journal of asthma : official journal of the Association for the Care of Asthma · 2024Article
- FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies.Human molecular genetics · 2023Article
- Winds of change a tale of: asthma and microbiome.Frontiers in microbiology · 2023Review
- A nationwide survey of the association between nonalcoholic fatty liver disease and the incidence of asthma in Korean adults.PloS one · 2022Article
- An Elevated METS-IR Index Is Associated With Higher Asthma Morbidity and Earlier Age of First Asthma in US Adults: Results Based on a Cross-Sectional Study.Frontiers in endocrinology · 2022Article
- Additive Effect of Obesity and Dyslipidemia on Wheezing in Korean Adults: A Nationwide Representative Survey Study.Allergy, asthma & immunology research · 2021Article
- Pulmonary function changes in older adults with and without metabolic syndrome.Scientific reports · 2021Article
- The association between serum apolipoprotein B and fractional exhaled nitric oxide in bronchial asthma patients.Journal of thoracic disease · 2021Article
- Article
- Serum insulin-like growth factor-1, asthma, and lung function among British adults.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Article
- High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions.Biomedicines · 2020Review
- Poor prognosis of NSCLC located in lower lobe is partly mediated by lower frequency of EGFR mutations.Scientific reports · 2020Article
- Metabolic Dysfunction and Asthma: Current Perspectives.Journal of asthma and allergy · 2020Review
- Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Effect of overweight/obesity on relationship between fractional exhaled nitric oxide and airway hyperresponsiveness in Chinese elderly patients with asthma.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The burden of asthma in the elderly is increasing, but the etiology of asthma in the elderly is not clearly understood. Recent studies have reported the epidemiological link between metabolic syndrome (MS) and asthma, but it has rarely been studied in the elderly. This study investigated the association between MS and asthma and the contribution of insulin resistance (IR) and systemic inflammation to this MS-asthma association in the elderly. Our study analyzed 4,060 elderly participants (≥65 years old) from a cross-sectional survey, the Korean National Health and Nutritional Examination Survey 2007-2012. Mediation analyses were performed to examine whether IR and systemic inflammation mediates the MS-asthma association. Participants with MS had significantly higher prevalence of asthma (adjusted odds ratio = 1.34; 95% confidence interval = 1.09-1.64), and those who had greater waist circumference and lower HDL-C were especially likely to have asthma. Participants with IR and systemic inflammation were associated with higher prevalence of asthma. Prevalence of IR and systemic inflammation were higher in participants with MS or with each MS component. The MS-asthma association was substantially mediated by IR and systemic inflammation. Our study showed a significant association between MS and asthma in the elderly. MS might affect asthma through both IR and systemic inflammation.
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