Evidence map›Paper›PMID 29925776›Full record

ArticleInternational journal of molecular sciences2018

Yeast-Based Screen to Identify Natural Compounds with a Potential Therapeutic Effect in Hailey-Hailey Disease.

Graziella Ficociello, Azzurra Zonfrilli, Samantha Cialfi, Claudio Talora, Daniela Uccelletti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Virulence · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Graziella FicocielloDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy. graaziella.ficociello@uniorma1.it.
Azzurra ZonfrilliDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy. azzurra.zonfrilli@uniroma1.it.
Samantha CialfiDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy. samantha.cialfi@uniroma1.it.
Claudio TaloraDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy. claudio.talora@uniroma1.it.
Daniela UccellettiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy. daniela.uccelletti@uniroma1.it.ORCID 0000-0001-6841-8129
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term orthodisease defines human disorders in which the pathogenic gene has orthologs in model organism genomes. Yeasts have been instrumental for gaining insights into the molecular basis of many human disorders, particularly those resulting from impaired cellular metabolism. We and others have used yeasts as a model system to study the molecular basis of Hailey-Hailey disease (HHD), a human blistering skin disorder caused by haploinsufficiency of the gene

Indexed as

Biological ProductsCalciumCalcium-Transporting ATPasesCell LineCell WallFungal ProteinsGenetic PleiotropyHumansKaempferolsKeratinocytesKluyveromycesMitochondriaNF-E2-Related Factor 2Oxidative StressPemphigus, Benign FamilialPrimary Cell CultureATP2C1 protein, humanBiological ProductsCalciumCalcium-Transporting ATPasesFungal ProteinskaempferolKaempferolsNFE2L2 protein, humanNF-E2-Related Factor 2Hailey-HaileyNOTCH1NRF2oxidative-stress

Identifiers

PMID29925776
PMCPMC6032253
OpenAlexW2809325582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.