Evidence map›Paper›PMID 29925634›Full record

ArticleScience translational medicine2018

Tissue engineering toward temporomandibular joint disc regeneration.

Natalia Vapniarsky, Le W Huwe, Boaz Arzi, Meghan K Houghton, Mark E Wong, James W Wilson, David C Hatcher, Jerry C Hu, Kyriacos A Athanasiou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Natalia VapniarskyDepartment of Pathology, Microbiology, and Immunology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0003-3239-6233
Le W HuweDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0001-5996-2106
Boaz ArziDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Meghan K HoughtonDirectorate for Computer and Information Science and Engineering, National Science Foundation, Alexandria, VA 22314, USA.ORCID 0000-0001-9835-1199
Mark E WongDepartment of Oral and Maxillofacial Surgery, University of Texas School of Dentistry, Houston, TX 77054, USA.ORCID 0000-0002-7556-7592
James W WilsonDepartment of Oral and Maxillofacial Surgery, University of Texas School of Dentistry, Houston, TX 77054, USA.ORCID 0000-0002-1097-3418
David C HatcherDiagnostic Digital Imaging Center, Sacramento, CA 95825, USA.
Jerry C HuDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-0651-1461
Kyriacos A AthanasiouDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA. athens@uci.edu.ORCID 0000-0001-5387-8405

Funding

TMJ Disc RegenerationR01DE015038 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2004 to 2022
$6.1M
NIDCR NIH HHS R01 DE015038
6 · The paper itself

Abstract

Treatments for temporomandibular joint (TMJ) disc thinning and perforation, conditions prevalent in TMJ pathologies, are palliative but not reparative. To address this, scaffold-free tissue-engineered implants were created using allogeneic, passaged costal chondrocytes. A combination of compressive and bioactive stimulation regimens produced implants with mechanical properties akin to those of the native disc. Efficacy in repairing disc thinning was examined in minipigs. Compared to empty controls, treatment with tissue-engineered implants restored disc integrity by inducing 4.4 times more complete defect closure, formed 3.4-fold stiffer repair tissue, and promoted 3.2-fold stiffer intralaminar fusion. The osteoarthritis score (indicative of degenerative changes) of the untreated group was 3.0-fold of the implant-treated group. This tissue engineering strategy paves the way for developing tissue-engineered implants as clinical treatments for TMJ disc thinning.

Indexed as

RegenerationAllograftsAnimalsChondrocytesImaging, Three-DimensionalImmune ToleranceImplants, ExperimentalOsteoarthritisSwineSwine, MiniatureTemporomandibular Joint DiscTissue Engineering

Identifiers

PMID29925634
PMCPMC6553461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.