ArticleProceedings. Biological sciences2018
The evolution of juvenile susceptibility to infectious disease.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Intestinal Parasite Community Dynamics in the Critically Endangered Chinese Alligator (Ecology and evolution · 2026Article
- Drivers of Viral Diversity and Sharing in Marine Mammals.Molecular ecology · 2026Article
- Pathogens pull hardest in the coevolutionary arms-race to determine age-specific transmission biases.bioRxiv : the preprint server for biology · 2025Article
- Disease resistance is more costly at younger ages: An explanation for the maintenance of juvenile susceptibility in a wild plant.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Season, size, and sex: factors influencing monogenean prevalence and intensity on Gambusia affinis in New Zealand.Parasitology research · 2024Article
- Coevolution of Age-Structured Tolerance and Virulence.Bulletin of mathematical biology · 2024Article
- Article
- How behavioural ageing affects infectious disease.Neuroscience and biobehavioral reviews · 2023Review
- The Evolution of the Age of Onset of Resistance to Infectious Disease.Bulletin of mathematical biology · 2023Article
- Meta-Analysis of the Effects of Insect Pathogens: Implications for Plant Reproduction.Pathogens (Basel, Switzerland) · 2023Review
- The evolution of age-specific resistance to infectious disease.Proceedings. Biological sciences · 2023Article
- Age-dependent relationships among diet, body condition, and Echinococcus multilocularis infection in urban coyotes.PloS one · 2023Article
- Asymmetric interactions between barley yellow dwarf virus -PAV and wheat dwarf virus in wheat.Frontiers in plant science · 2023Article
- Helminth parasites are associated with reduced survival probability in young red deer.Parasitology · 2022Article
- Can disease resistance evolve independently at different ages? Genetic variation in age-dependent resistance to disease in three wild plant species.The Journal of ecology · 2022Article
- Article
- Dynamics of Pathogenic Fungi in Field Hedges: Vegetation Cover Is Differentially Impacted by Weather.Microorganisms · 2022Article
- Coevolutionary theory of hosts and parasites.Journal of evolutionary biology · 2022Review
- What are the determinants of childhood infections in India's peri-urban slums? A case study of eight cities.PloS one · 2021Article
- Young but not defenceless: antifungal activity during embryonic development of a social insect.Royal Society open science · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Infection prior to reproduction usually carries greater fitness costs for hosts than infection later in life, suggesting selection should tend to favour juvenile resistance. Yet, juveniles are generally more susceptible than adults across a wide spectrum of host taxa. While physiological constraints and a lack of prior exposure can explain some of this pattern, studies in plants and insects suggest that hosts may trade off juvenile susceptibility against other life-history traits. However, it is unclear precisely how trade-offs shape the evolution of juvenile susceptibility. Here, we theoretically explore the evolution of juvenile susceptibility subject to trade-offs with maturation or reproduction, which could realistically occur due to resource allocation during development (e.g. prioritizing growth over immune defence). We show how host lifespan, the probability of maturation (i.e. of reaching the adult stage) and transmission mode affect the results. Our key finding is that elevated juvenile susceptibility is expected to evolve over a wide range of conditions, but should be lowest when hosts have moderate lifespans and an intermediate probability of reaching the adult stage. Our results elucidate how interactions between trade-offs and the epidemiological-demographic structure of the population can lead to the evolution of elevated juvenile susceptibility.
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Registered trials
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