Evidence map›Paper›PMID 29925616›Full record

ArticleProceedings. Biological sciences2018

Adaptive developmental plasticity in rhesus macaques: the serotonin transporter gene interacts with maternal care to affect juvenile social behaviour.

Jesus E Madrid, Tara M Mandalaywala, Sean P Coyne, Jamie Ahloy-Dallaire, Joseph P Garner, Christina S Barr, Dario Maestripieri, Karen J Parker

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jesus E MadridNeurosciences Program, Stanford University, Stanford, CA 94305, USA jemadrid@stanford.edu.ORCID 0000-0002-2477-2086
Tara M MandalaywalaDepartment of Psychological and Brain Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Sean P CoyneDepartment of Psychology, Notre Dame of Maryland University, Baltimore, MD 21210, USA.
Jamie Ahloy-DallaireDepartment of Comparative Medicine, Stanford University, Stanford, CA 94305, USA.
Joseph P GarnerDepartment of Psychiatry and Behavioural Sciences, Stanford University, Stanford, CA 94305, USA.
Christina S BarrNational Institute of Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20892, USA.
Dario MaestripieriDepartment of Comparative Human Development, The University of Chicago, Chicago, IL 60637, USA.
Karen J ParkerDepartment of Psychiatry and Behavioural Sciences, Stanford University, Stanford, CA 94305, USA kjparker@stanford.edu.

Funding

Translational Science InitiativeP40OD012217 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2012 to 2026
$40.4M
Cross-Species Genetic and Epigenetic Studies of Stress Response and RewardZIAAA000311 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI BARR, CHRISTINA · 2010 to 2020
$14.0M
Early experience and emotional development in free-ranging primatesR01HD067175 · NICHD · UNIVERSITY OF CHICAGO · PI MAESTRIPIERI, DARIO, PARKER, KAREN J. · 2011 to 2015
$1.6M
NICHD NIH HHS R01 HD067175NIH HHS P40 OD012217
6 · The paper itself

Abstract

Research has increasingly highlighted the role that developmental plasticity-the ability of a particular genotype to produce variable phenotypes in response to different early environments-plays as an adaptive mechanism. One of the most widely studied genetic contributors to developmental plasticity in humans and rhesus macaques is a serotonin transporter gene-linked polymorphic region (5-HTTLPR), which determines transcriptional efficiency of the serotonin transporter gene

Indexed as

Adaptation, PhysiologicalMaternal BehaviorSocial BehaviorAnimalsFemaleMacaca mulattaMaleSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport Proteins5-HTTLPRdevelopmental plasticityG×Ematernal carerhesus macaquesocial play

Identifiers

PMID29925616
PMCPMC6030517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.