ArticleMalaria journal2018
Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group.
Abstract readConference Proceedings
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Article in Malaria journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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39citing papers in PubMed, 3 pooled it
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis.The Lancet. Infectious diseases · 2024Pooled it
- Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis.Malaria journal · 2023Pooled it
- Tafenoquine: a toxicity overview.Expert opinion on drug safety · 2021Pooled it
- Risk perceptions of high-dose primaquine and tafenoquine amongBMJ global health · 2026Article
- PvGTSeq and PvCRiSP: Two amplicon-based targeted sequencing panels for Plasmodium vivax.PLoS neglected tropical diseases · 2026Article
- G6PD deficiency in Indonesia: a systematic review and update of prevalence and variant maps in the context of malaria elimination.The Lancet regional health. Western Pacific · 2026Article
- Temporal trends inmedRxiv : the preprint server for health sciences · 2026Article
- Moving towards high-dose primaquine or single-dose tafenoquine for Plasmodium vivax treatment in Cambodia: a meeting report from dissemination of results of the EFFORT trial to stakeholders.Malaria journal · 2026Article
- The cost-effectiveness of tafenoquine following screening with STANDARD™ G6PD screening for the treatment of vivax malaria in the Brazilian Public Health System.Lancet regional health. Americas · 2025Article
- Perceptions of shorter radical cure Plasmodium vivax treatment regimens and their implementation: a qualitative study among stakeholders in Cambodia.Malaria journal · 2025Article
- Piloting the options assessment toolkit with national malaria programme leaders from the Asia-Pacific countries: a meeting report.Malaria journal · 2025Article
- Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics.The Lancet. Infectious diseases · 2025Article
- Linked-evidence modelling of qualitative G6PD testing to inform low- and intermediate-dose primaquine treatment for radical cure of Plasmodium vivax.PLoS neglected tropical diseases · 2024Article
- Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.Science advances · 2024Article
- Radical cure for Plasmodium vivax malaria after G6PD qualitative testing in four provinces in Cambodia, results from Phase I implementation.Malaria journal · 2024Article
- Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model.PLoS medicine · 2024Article
- Supervised administration of primaquine may enhance adherence to radical cure forThe Lancet regional health. Southeast Asia · 2023Review
- A Review of the Current Status of G6PD Deficiency Testing to Guide Radical Cure Treatment for Vivax Malaria.Pathogens (Basel, Switzerland) · 2023Review
- Individual variation in Plasmodium vivax malaria risk: Are repeatedly infected people just unlucky?PLoS neglected tropical diseases · 2023Review
- Plasmodium vivax in Children: Hidden Burden and Conspicuous Challenges, a Narrative Review.Infectious diseases and therapy · 2023Review
Corrections and comments
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Authors and funding
98 authors.
Kamala ThriemerGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Darwin, NT, 0810, Australia. kamala.ley-thriemer@menzies.edu.au.ORCID http://orcid.org/0000-0001-7536-7497
Albino BobogareMinistry of Health and Medical Services, National Vector-Borne Disease Control Programme, Honiara, Solomon Islands.
Benedikt LeyGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Darwin, NT, 0810, Australia.
Clarice Samo GudoIndependent Consultant, Amsterdam, The Netherlands.
Mohammad Shafiul AlamInternational Center for Diarrheal Diseases (ICDDR,B), Dhaka, Bangladesh.
Nick M AnsteyGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Darwin, NT, 0810, Australia.
Elizabeth AshleyMyanmar-Oxford Clinical Research Unit, Yangon, Myanmar.
J Kevin BairdCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
Charlotte GryseelsInstitute of Tropical Medicine Antwerp, Antwerp, Belgium.
Elodie JambertMedicines for Malaria Venture (MMV), Geneva, Switzerland.
Marcus LacerdaInstituto Leônidas & Maria Deane (Fiocruz), Manaus, Amazonas, Brazil.
Ferdinand LaihadNational Forum on Indonesia RBM/National Forum on Gebrak Malaria, Jakarta, Indonesia.
Jutta MarfurtGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Darwin, NT, 0810, Australia.
Ayodhia Pitaloka PasaribuUniversitas Sumatera Utara, Medan, Indonesia.
Jeanne Rini PoespoprodjoYayasan Pengembangan Kesehatan dan Masyarakat, Papua (YPKMP), Papua, Indonesia.
Inge SutantoUniversity of Indonesia, Jakarta, Indonesia.
Walter R TaylorCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
Christel van den BoogaardGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Darwin, NT, 0810, Australia.
Katherine E BattleMalaria Atlas Project (MAP), Big Data Institute, University of Oxford, Oxford, UK.
Lek DysoleyNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Prakash GhimireMicrobiology Department, Tribhuvan University, Kathmandu, Nepal.
Bill HawleyEntomology Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, USA.
Jimee HwangPresident's Malaria Initiative, Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, USA.
Wasif Ali KhanInternational Center for Diarrheal Diseases (ICDDR,B), Dhaka, Bangladesh.
Rose Nani Binti MudinDisease Control Division, Ministry of Health, Putrajaya, Malaysia.
Maria Endang SumiwiUNICEF Indonesia, Jakarta, Indonesia.
Rukhsana AhmedLiverpool School of Tropical Medicine, Liverpool, UK.
M M AktaruzzamanDirectorate General of Health Services, Ministry of Health & Family Welfare Government of the People's Republic of Bangladesh, Dhaka, Bangladesh.
Kiran Raj AwasthiSave The Children, Kathmandu, Nepal.
Azucena BardajiISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
David BellIntellectual Ventures Global Good Fund, Bellevue, USA.
Leonard BoazMinistry of Health and Medical Services, National Vector-Borne Disease Control Programme, Honiara, Solomon Islands.
Faustina Helen BurdamYayasan Pengembangan Kesehatan dan Masyarakat, Papua (YPKMP), Papua, Indonesia.
Daniel ChandramohanThe London School of Hygiene & Tropical Medicine (LSHTM), London, UK.
Qin ChengAustralian Defence Force Malaria and Infectious Disease Institute, Enoggera, Australia.
Keobouphaphone ChindawongsaCenter of Malariology, Parasitology and Entomology, Communicable Diseases Control, Vientiane, Lao PDR.
Janice CulpepperBill & Melinda Gates Foundation, Seattle, USA.
Santasabuj DasIndian Council of Medical Research, New Delhi, India.
Raffy DerayDepartment of Health, National Centre for Disease Control & Prevention, Manila, Philippines.
Meghna DesaiMalaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, USA.
Gonzalo DomingoPATH, Seattle, USA.
Wang DuoquanNational Institute of Parasitic Diseases, China CDC, Shanghai, China.
Stephan DuparcMedicines for Malaria Venture (MMV), Geneva, Switzerland.
Rustini FloranitaWHO Office, Jakarta, Indonesia.
Emily Gerth-GuyettePATH, Seattle, USA.
Rosalind E HowesMalaria Atlas Project (MAP), Big Data Institute, University of Oxford, Oxford, UK.
Cecilia HugoACTMalaria, Manila, Philippines.
George JagoeMedicines for Malaria Venture (MMV), Geneva, Switzerland.
Elvieda SariwatiMinistry of Health, National Malaria Control Program, Jakarta, Indonesia.
Sanya Tahmina JhoraDirectorate General of Health Services, Ministry of Health & Family Welfare Government of the People's Republic of Bangladesh, Dhaka, Bangladesh.
Wu JinweiTengchong Center for Disease Control and Prevention, Tengchong, China.
Harin KarunajeewaWalter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Enny KenangalemYayasan Pengembangan Kesehatan dan Masyarakat, Papua (YPKMP), Papua, Indonesia.
Bibek Kumar LalEpidemiology & Disease Control Division, Department of Health Services, Ministry of Health and Population, Kathmandu, Nepal.
Chandra LanduwulangPapuan Health and Community Development Foundation, Timika, Indonesia.
Emmanuel Le PerruMinistry of Health, Kathmandu, Nepal.
Sang-Eun LeeDivision of Vectors and Parasitic Diseases, Korea Centers for Disease Control and Prevention, Seoul, South Korea.
Leo Sora MakitaMinistry of Health, National Malaria Control Programme, Port Mosby, Papua New Guinea.
James McCarthyQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Asrat MekuriaSchool of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Neelima MishraIndian Council of Medical Research, New Delhi, India.
Esau NaketMinistry of Health, Malaria and Other Vector-Borne Diseases Control Program (MOVBDCP), Port Vila, Vanuatu.
Simone NambanyaCenter of Malariology, Parasitology and Entomology, Communicable Diseases Control, Vientiane, Lao PDR.
Johnny NausienMinistry of Health, Malaria and Other Vector-Borne Diseases Control Program (MOVBDCP), Port Vila, Vanuatu.
Thang Ngo DucNational Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi, Vietnam.
Thuan Nguyen ThiNational Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi, Vietnam.
Rinitis NoviyantiEijkman Institute for Molecular Biology, Jakarta, Indonesia.
Daniel PfefferGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Darwin, NT, 0810, Australia.
Gao QiJiangsu Institute of Parasitic Diseases, Wuxi, China.
Annisa RahmaliaTuberculosis-HIV Research Center Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Stephen RogersonDepartment of Medicine at the Doherty Institute, University of Melbourne, Melbourne, Australia.
Iriani SamadMinistry of Health, National Malaria Control Program, Jakarta, Indonesia.
Jetsumon SattabongkotMahidol Vivax Research Unit, Faculty of Tropical Medicine, Bangok, Thailand.
Ari SatyagrahaEijkman Institute for Molecular Biology, Jakarta, Indonesia.
Dennis ShanksAustralian Defence Force Malaria and Infectious Disease Institute, Enoggera, Australia.
Surender Nath SharmaNational Vector Borne Disease Control Programme Directorate General of Health Services Ministry of Health & Family Welfare, New Delhi, India.
Carol Hopkins SibleyWorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.
Ali SungkarFamily Health Directorate, Ministry of Health, Jakarta, Indonesia.
Din SyafruddinEijkman Institute for Molecular Biology, Jakarta, Indonesia.
Arunansu TalukdarMedicine Department, Medical College Kolkata, Kolkata, India.
Joel TarningMahidol Oxford Clinical Research Unit (MORU), Bangkok, Thailand.
Feiko Ter KuileLiverpool School of Tropical Medicine, Liverpool, UK.
Suman ThapaSave The Children, Kathmandu, Nepal.
Minerva TheodoraMinistry of Health, National Malaria Control Program, Jakarta, Indonesia.
Tho Tran HuyNational Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi, Vietnam.
Edward WaraminFamily Health Services, Ministry of Health, Port Mosby, Papua New Guinea.
Govert WaramoriFreeport Indonesia, Kuala Kencana, Indonesia.
Adugna WoyessaEthiopian Public Health Institute (EPHI), Addis Ababa, Ethiopia.
Chansuda WongsrichanalaiIndependent Consultant, Bangkok, Thailand.
Nguyen Xuan XaNational Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi, Vietnam.
Joon Sup YeomYonsei University College of Medicine, Seoul, South Korea.
Lukas HermawanFamily Health Directorate, Ministry of Health, Jakarta, Indonesia.
Angela DevineGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Darwin, NT, 0810, Australia.
Spike NowakPATH, Seattle, USA.
Indra JayaProgram and Information Department, Directorate General of Disease Prevention and Control, Jakarta, Indonesia.
Supargiyono SupargiyonoUniversity of Gadjah Mada, Yogyakarta, Indonesia.
Koen Peeters GrietensInstitute of Tropical Medicine Antwerp, Antwerp, Belgium.
Ric N PriceGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Darwin, NT, 0810, Australia.
Funding
Bill and Melinda Gates Foundation OPP1164105DFAT NAMedical Research Council G1100654Wellcome Trust 200909/Z/16/Z
Abstract
The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.
Indexed as
AntimalarialsAsiaHumansMalaria, VivaxPacific IslandsPlasmodium vivaxPrimaquineTreatment Adherence and ComplianceTreatment OutcomeAntimalarialsPrimaquineAdherenceAPMENEffectivenessEfficacyPlasmodium vivaxPrimaquineRadical cureVivax malaria
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