Evidence map›Paper›PMID 29925344›Full record

ArticleBMC pregnancy and childbirth2018

Vitamin D levels in an Australian and New Zealand cohort and the association with pregnancy outcome.

Rebecca L Wilson, Alison J Leviton, Shalem Y Leemaqz, Paul H Anderson, Jessica A Grieger, Luke E Grzeskowiak, Petra E Verburg, Lesley McCowan, Gustaaf A Dekker, Tina Bianco-Miotto and 1 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  7. Associations Between Prenatal Vitamin D and Placental Gene Expression.bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Rebecca L WilsonRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Alison J LevitonRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Shalem Y LeemaqzRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Paul H AndersonSchool of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Jessica A GriegerRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Luke E GrzeskowiakRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Petra E VerburgRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Lesley McCowanDepartment of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.
Gustaaf A DekkerRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Tina Bianco-MiottoRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Claire T RobertsRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia. claire.roberts@adelaide.edu.au.ORCID http://orcid.org/0000-0002-9250-2192
The University of Adelaide · AULyell McEwin Hospital · AUUniversity Medical Center Groningen · NLUniversity of Auckland · NZUniversity of South Australia · AUWine Australia · AU

Funding

Health Research Council of New Zealand 04/198National Health and Medical Research Council APP1070421National Health and Medical Research Council GNT1020749National Health and Medical Research Council GNT1020754National Health and Medical Research Council GNT1051858
6 · The paper itself

Abstract

backgroundPregnant women are at increased susceptibility to vitamin D deficiency. Hence, there is continuing interest in determining how vitamin D influences pregnancy health. We aimed to compare vitamin D status in two distinct populations of pregnant women in Australia and New Zealand and to investigate the relationship between vitamin D status and pregnancy outcome. This included evaluating possible effect measure modifications according to fetal sex.

methodsSerum 25-hydroxy vitamin D (25(OH)D) was measured at 15 ± 1 weeks' gestation in 2800 women from Adelaide and Auckland who participated in the multi-centre, prospective cohort SCreening fOr Pregnancy Endpoints (SCOPE) study.

resultsMean serum 25(OH)D in all women was 68.1 ± 27.1 nmol/L and 28% (n = 772) were considered vitamin D deficient (< 50 nmol/L). Serum 25(OH)D was lower in the women recruited in Adelaide when compared to the women recruited in Auckland and remained lower after adjusting for covariates including maternal body mass index and socioeconomic index (Adelaide: 58.4 ± 50.3 vs. Auckland: 70.2 ± 54.5 nmol/L, P < 0.001). A 53% decreased risk for gestational diabetes mellitus (GDM) was observed with high (> 81 nmol/L) "standardised" vitamin D status when compared to moderate-high (63-81 nmol/L, aRR, 0.47; 95% CI: 0.23, 0.96). Marginal sex-specific differences occurred between vitamin D status and GDM: women carrying a female fetus had a 56% decreased risk for GDM in those with low-moderate levels of standardised vitamin D (44-63 nmol/L) compared to moderate-high levels (aRR: 0.44; 95% CI: 0.20, 0.97), whilst in women carrying a male fetus, a 55% decreased risk of GDM was found with high standardised vitamin D when compared to moderately-high vitamin D, but this was not statistically significant (aRR: 0.45; 95% CI: 0.15, 1.38).

conclusionsHigh serum 25(OH)D at 15 ± 1 weeks' gestation was shown to be protective against the development of GDM. A possible association between fetal sex, vitamin D status and GDM provides further questions and encourages continual research and discussion into the role of vitamin D in pregnancy, particularly in vitamin D replete populations.

Indexed as

AdolescentAdultAustraliaDiabetes, GestationalFemaleGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgeMaleNew ZealandPregnancyPregnancy OutcomePremature BirthProspective StudiesProtective Factors25-hydroxyvitamin DVitamin DFetal sexGestational diabetes mellitusPregnancyPregnancy outcomeVitamin D

Identifiers

PMID29925344
PMCPMC6011374
OpenAlexW2809418074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.