Evidence map›Paper›PMID 29925328›Full record

Trial reportBMC anesthesiology2018

The role of Gabapentin oral solution in decreasing desflurane associated emergence agitation and delirium in children after stabismus surgery, a prospective randomized double-blind study.

Ahmed A Badawy, Samaa A Kasem, Doaa Rashwan, Tarek Al Menesy, Ghada Adel, Ali M Mokhtar, Yasmin A Badawy

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03347916 naunknown statusnot on this map

The Role of Gabapentin Oral Solution in Decreasing Desflurane Associated Emergence Agitation and Delirium in Children After Strabismus Surgery: A Prospective Randomized Double-blind Study

TypeinterventionalSponsorKuwait Specialized Eye CenterRan2017 to 2017Enrolled75ConditionsEmergence Agitation After Desflurane AnesthesiaArmsStrawberry juice as (placebo), Gabapentin Oral Solution [Neurontin]
NCT06887998 phase3not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Two Different Doses of Oral Gabapentin on Sevoflurane-associated Emergence Agitation and Delirium in Adult Patients After Nasal Surgery. A Prospective Controlled, Randomized, Double-blinded Study.

TypeinterventionalSponsorCairo UniversityRan2025 to 2026Enrolled63ConditionsEmergence AgitationArmsGabapentin 600 mg capsules, Gabapentin 400 mg capsules, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ahmed A BadawyAnesthesia department, Faculty of medicine, Cairo University, Giza, Egypt. dr.ahmedbadawy545@gmail.com.ORCID 0000-0001-5152-9391
Samaa A KasemAnesthesia department, Faculty of medicine, Beni Suef University, Beni Suef, Egypt.
Doaa RashwanAnesthesia department, Faculty of medicine, Beni Suef University, Beni Suef, Egypt.
Tarek Al MenesyAnesthesia department, Faculty of medicine, Beni Suef University, Beni Suef, Egypt.
Ghada AdelAnesthesia department, Faculty of medicine, Cairo University, Giza, Egypt.
Ali M MokhtarAnesthesia department, Faculty of medicine, Cairo University, Giza, Egypt.
Yasmin A BadawyFaculty of Medicine, Cairo University, Giza, Egypt.
Cairo University · EGBeni-Suef University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundShort acting inhalational anesthetic (Desflurane) produces emergence agitation (EA) in pediatrics with an incidence up to 80%. The aim of the present study was to examine the role of Gabapentin oral solution in attenuating desflurane associated EA in children after strabismus surgery under general anesthesia.

methodsSeventy patients, 2-6 years old, scheduled for strabismus surgery were randomly allocated into two groups (35 each); Control group (c): received 5 ml of oral strawberry juice (placebo) and Gabapentin group (G) received 5 mg/Kg gabapentin oral solution in 5 ml strawberry juice, 1 h before anesthesia. Patient separation, cooperation, emergence incidence and emergence severity were assessed. Also time to extubation and time to emergence, duration of PACU stay, PONV and number of patients required meperidine postoperatively were recorded.

resultsDuration to extubation and duration to emergence were statistically prolonged in gabapentin group compared to the control group. The incidence of EA and its severity were reduced in gabapentin group with more tendencies to be asleep and less attentive. More patients in the control group required postoperative meperidine to reduce crying and agitation.

conclusionOral gabapentin 5 mg/kg reduced the incidence and severity scoring of emergence agitation (by 20%) with more tendencies for sleeping with preserved response to stimuli in PACU.

trial registrationNumber: NCT03347916 , date: November 17, 2017, retrospectively.

Indexed as

Administration, OralAnesthesia, GeneralAnesthetics, InhalationChildChild, PreschoolDesfluraneDouble-Blind MethodEmergence DeliriumFemaleGabapentinHumansMalePostoperative ComplicationsPsychomotor AgitationStrabismusAnesthetics, InhalationDesfluraneGabapentinDesfluraneEmergence agitationGabapentinStrabismus

Identifiers

PMID29925328
PMCPMC6011346
OpenAlexW2808792621

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.