Evidence map›Paper›PMID 29925041›Full record

ReviewReproductive toxicology (Elmsford, N.Y.)2018

Effects of bisphenol A and its analogs on reproductive health: A mini review.

Jacob Steven Siracusa, Lei Yin, Emily Measel, Shenuxan Liang, Xiaozhong Yu

Abstract readReview
In one paragraph

Review in Reproductive toxicology (Elmsford, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it, 333 citations in OpenAlex.

  1. Pooled it
  2. Bisphenol S and female reproductive toxicity: a scoping review of human studies.Journal of exposure science & environmental epidemiology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Biodegradation of the endocrine-disrupting compound bisphenol F byApplied and environmental microbiology · 2025
    Article
  12. Article
  13. Microplastic-Mediated Delivery of Di-butyl Phthalate AltersMicroplastics (Basel, Switzerland) · 2025
    Article
  14. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jacob Steven SiracusaDepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States.
Lei YinDepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States; ReproTox Biotech LLC, Athens 30602, GA, United States.
Emily MeaselDepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States.
Shenuxan LiangDepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States.
Xiaozhong YuDepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States. Electronic address: yuxz@uga.edu.
University of Georgia · US

Funding

Three-dimensional testicular cell co-culture model for reproductive toxicity screeningR44ES027374 · NIEHS · REPROTOX BIOTECH, LLC · PI YIN, LEI · 2018 to 2019
$1.5M
A 3D Mini-Testis Model for Reproductive Toxicity TestingR21OH010473 · OH · UNIVERSITY OF GEORGIA · PI YU, XIAOZHONG · 2013 to 2014
$405k
Establishment of human mini-Testis for reproductive toxicity testingR43ES031890 · NIEHS · REPROTOX BIOTECH, LLC · PI YIN, LEI · 2020 to 2020
$225k
Innovative three-dimensional testicular Co-culture (Mini-Testis) model for reproductive toxicity testing: a pathway based High throughput (HT) and High Content Analysis (HCA)R43ES027374 · NIEHS · REPROTOX BIOTECH, LLC · PI YIN, LEI · 2016 to 2016
$202k
NIEHS NIH HHS R43 ES027374NIEHS NIH HHS R43 ES031890NIEHS NIH HHS R44 ES027374NIOSH CDC HHS R21 OH010473
6 · The paper itself

Abstract

Known endocrine disruptor bisphenol A (BPA) has been shown to be a reproductive toxicant in animal models. Its structural analogs: bisphenol S (BPS), bisphenol F (BPF), bisphenol AF (BPAF), and tetrabromobisphenol A (TBBPA) are increasingly being used in consumer products. However, these analogs may exert similar adverse effects on the reproductive system, and their toxicological data are still limited. This mini-review examined studies on both BPA and BPA analog exposure and reproductive toxicity. It outlines the current state of knowledge on human exposure, toxicokinetics, endocrine activities, and reproductive toxicities of BPA and its analogs. BPA analogs showed similar endocrine potencies when compared to BPA, and emerging data suggest they may pose threats as reproductive hazards in animal models. While evidence based on epidemiological studies is still weak, we have utilized current studies to highlight knowledge gaps and research needs for future risk assessments.

Indexed as

AnimalsBenzhydryl CompoundsBisphenol A CompoundsEndocrine DisruptorsFemaleHumansMalePhenolsReproductive HealthBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsPhenolsBisphenol ABisphenol AFBisphenol FBisphenol SReproductive toxicityTetrabromobisphenol A

Identifiers

PMID29925041
PMCPMC6689411
OpenAlexW2809403670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.