ArticleBiophysical journal2018
Principles for Optimal Cooperativity in Allosteric Materials.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- 3D self-locking granular metamaterials.Science advances · 2026Article
- Evolutionary pathways in epistatic mechanical networks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Learning to learn by using nonequilibrium training protocols for adaptable materials.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Allosteric communication in molecular machines via information exchange: what can be learned from dynamical modeling.Biophysical reviews · 2020Review
- Direct coupling analysis of epistasis in allosteric materials.PLoS computational biology · 2020Article
- Mechanics of Allostery: Contrasting the Induced Fit and Population Shift Scenarios.Biophysical journal · 2019Article
- Universality of fold-encoded localized vibrations in enzymes.Scientific reports · 2019Article
- Allostery in Its Many Disguises: From Theory to Applications.Structure (London, England : 1993) · 2019Review
- Revealing evolutionary constraints on proteins through sequence analysis.PLoS computational biology · 2019Article
- Designed Elastic Networks: Models of Complex Protein Machinery.International journal of molecular sciences · 2018Review
- Entropy favors heterogeneous structures of networks near the rigidity threshold.Nature communications · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allosteric proteins transmit a mechanical signal induced by binding a ligand. However, understanding the nature of the information transmitted and the architectures optimizing such transmission remains a challenge. Here we show, using an in silico evolution scheme and theoretical arguments, that architectures optimized to be cooperative, which efficiently propagate energy, qualitatively differ from previously investigated materials optimized to propagate strain. Although we observe a large diversity of functioning cooperative architectures (including shear, hinge, and twist designs), they all obey the same principle of displaying a mechanism, i.e., an extended soft mode. We show that its optimal frequency decreases with the spatial extension L of the system as L
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