ArticleCell reports2018
Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence.
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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116 citing papers in PubMed, 155 citations in OpenAlex.
- Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase-A1.Physiological reports · 2026Article
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- Mitochondrial Distress Signals at the Heart-Liver Interface: Molecular Links Between MASLD and Heart Failure.International journal of molecular sciences · 2026Review
- Hyperbaric Oxygen Attenuates Cerebral Ischemia-Reperfusion Injury Through ROS-Dependent Remodeling of Microglial Mitochondrial Dynamics.International journal of molecular sciences · 2026Article
- Redox signals and oxidative stress in the control of mitochondrial protein import.Protein science : a publication of the Protein Society · 2026Review
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- Photobiomodulation repairs the blood-spinal cord barrier in a mouse model of spinal cord injury.Neural regeneration research · 2026Article
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- Endothelial Drp1 integrates VEGF-induced redox signaling with glycolysis through cysteine oxidation to drive angiogenesis.Nature communications · 2026Article
- [Research progress on the metabolic regulatory mechanisms of coronary collateral circulation].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Dynamin-Related Protein 1 (Drp1) in Inflammatory Bowel Disease: Molecular Pathways Connecting Mitochondrial Dynamics with Intestinal Inflammation and Homeostasis.International journal of molecular sciences · 2026Review
- Hyperglycemia-Induced Endothelial Dysfunction: From Classical Pathogenetic Mechanisms to Emerging Insights into ACE2 Protective Action.International journal of molecular sciences · 2026Review
- A mechanism for the disrupted redox regulation of vascular contractility during aging.iScience · 2026Article
- Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Endoplasmic Reticulum Redoxome: Protein Folding and Beyond.Biochemistry · 2026Review
- Inhibition of Pathological Mitochondrial Fission in Retinal Pigment Epithelium Mitigates Choroidal Neovascularization.Investigative ophthalmology & visual science · 2026Article
- Mitochondria-mediated inflammation and diabetic wound healing: mechanisms and therapeutic strategies.Frontiers in pharmacology · 2026Review
- Endothelial mitochondrial homeostasis in the development and progression of atherosclerosis.Frontiers in cardiovascular medicine · 2026Review
- Berberine suppresses mechanical stretch-induced apoptosis and proliferation in vascular smooth muscle cells via ROS/PDI/Drp1 signaling pathway.Frontiers in pharmacology · 2026Article
56 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 3 institutions in 1 country.
Young-Mee KimVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Seock-Won YounVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Varadarajan SudhaharVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
Archita DasVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Reyhaan ChandhriDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA; Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Henar Cuervo GrajalDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA; Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Junghun KweonDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA.
Silvia LeanhartVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
Lianying HeVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Peter T TothDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA.
Jan KitajewskiDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA; Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Jalees RehmanDepartments of Medicine (Cardiology) and Pharmacology, University of Illinois at Chicago, Chicago, IL, USA.
Yisang YoonDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Jaehyung ChoDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA.
Tohru FukaiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA; Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, GA, USA; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
Masuko Ushio-FukaiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA; Department of Medicine (Cardiology), Medical College of Georgia at Augusta University, Augusta, GA, USA. Electronic address: mfukai@augusta.edu.
University of Illinois Chicago · USAugusta University · USCharlie Norwood VA Medical Center · US
Funding
TRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6MNotch in Angiogenesis and Vascular BiologyR01HL112626 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jan K. Kitajewski · 2012 to 2026
$6.3MVascular Extracellular Superoxide Dismutase ModulationR01HL070187 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKAI, TOHRU · 2002 to 2017
$4.2MThiol isomerases in neutrophil recruitment and thromboinflammatory diseaseR01HL130028 · NHLBI · WASHINGTON UNIVERSITY · PI CHO, JAEHYUNG · 2016 to 2024
$3.6MCopper transport protein and inflammatory angiogenesisR01HL116976 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2013 to 2016
$2.9MCu Transporting ATPase and Diabetic Vascular ComplicationsR01HL133613 · NHLBI · AUGUSTA UNIVERSITY · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2017 to 2020
$2.7MCLIC Function In AngiogenesisR01HL119043 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KITAJEWSKI, JAN K. · 2014 to 2017
$1.7MProtein Disulfide Isomerase as Novel Redox Sensor in VEGF SignalingR01HL135584 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI USHIO-FUKAI, MASUKO · 2017 to 2020
$1.5MRole of Cysteine Sulfenic Acid Formation in Compartmentalization of VEGF SignalinR21HL112293 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI USHIO-FUKAI, MASUKO · 2013 to 2014
$435kSUMOylation of Cu transport protein Atox1 in AtherosclerosisI01BX001232 · VA · JESSE BROWN VA MEDICAL CENTER · PI TOHRU FUKAI · 2012 to 2026
–BLRD VA I01 BX001232NHLBI NIH HHS R01 HL070187NHLBI NIH HHS R01 HL112626NHLBI NIH HHS R01 HL116976NHLBI NIH HHS R01 HL119043NHLBI NIH HHS R01 HL130028NHLBI NIH HHS R01 HL133613NHLBI NIH HHS R01 HL135584NHLBI NIH HHS R21 HL112293NHLBI NIH HHS T32 HL007829
Abstract
Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction. How redox signals regulate coupling between mitochondrial dynamics and endothelial (dys)function remains unknown. Here, we identify protein disulfide isomerase A1 (PDIA1) as a thiol reductase for the mitochondrial fission protein Drp1. A biotin-labeled Cys-OH trapping probe and rescue experiments reveal that PDIA1 depletion in ECs induces sulfenylation of Drp1 at Cys
Indexed as
Cellular SenescenceMitochondrial DynamicsAnimalsCell RespirationCysteineDiabetes Mellitus, Type 2DynaminsEndoplasmic Reticulum StressHumansHuman Umbilical Vein Endothelial CellsMiceMitochondriaMutationOxidation-ReductionProcollagen-Proline DioxygenaseProtein BindingCysteineDynaminsP4HB protein, humanP4hb protein, mouseProcollagen-Proline DioxygenaseProtein Disulfide-IsomerasesReactive Oxygen SpeciesangiogenesisdiabetesDrp1endothelial dysfunctionendothelial senescencemitochondrial fissionprotein disulfide isomerasereactive oxygen speciessulfenylation
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