ArticleMedicina oral, patologia oral y cirugia bucal2018
Survival study of leukoplakia malignant transformation in a region of northern Spain.
Article in Medicina oral, patologia oral y cirugia bucal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- A Retrospective Observational Study on Oral Leukoplakia Patients Adhering to the Mediterranean Diet From Southern Italy.International dental journal · 2026Observational
- Retinoic Acid Profiles in Proliferative Verrucous Versus Homogeneous Leukoplakia: A Preliminary Nested Case-Control Study.Biomedicines · 2025Article
- OralImmunoAnalyser: a software tool for immunohistochemical assessment of oral leukoplakia using image segmentation and classification models.Frontiers in artificial intelligence · 2024Article
- The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study.Journal of clinical medicine · 2023Article
- Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research.Journal of pharmacy & bioallied sciences · 2023Article
- Associations between clinical and histopathological characteristics in oral leukoplakia.Oral diseases · 2023Article
- Recurrence of Oral Leukoplakia after COCancers · 2022Article
- Characterization of initial/early histologic features of proliferative leukoplakia and correlation with malignant transformation: a multicenter study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Effect of clinical and histologic features on time to malignancy in 224 cases of oral leukoplakia treated by surgery.Clinical oral investigations · 2022Article
- Lichenoid areas may arise in early stages of proliferative verrucous leukoplakia: A long-term study of 34 patients.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2022Article
- Malignant Transformation Rate of Non-reactive Oral Hyperkeratoses Suggests an Early Dysplastic Phenotype.Head and neck pathology · 2022Review
- Gingival Leukoplakia: Hyperkeratosis with Epithelial Atrophy Is A Frequent Histopathologic Finding.Head and neck pathology · 2021Article
- Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Retraction: Oral leukoplakia, a clinical-histopathological study in 412 patients.Journal of clinical and experimental dentistry · 2021Article
- Difficulties in the Prognostic Study of Oral Leukoplakia: Standardisation Proposal of Follow-Up Parameters.Frontiers in oral health · 2021Review
- CD133 Role in Oral Carcinogenesis.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Oral leukoplakia, a clinical-histopathological study in 412 patients.Journal of clinical and experimental dentistry · 2020Article
- Expression of E- Cadherin and Levels of Dysplasia in Oral Leukoplakia - A Prospective Cohort Study.Asian Pacific journal of cancer prevention : APJCP · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral leukoplakia is the most common potentially malignant disorder (PMD) of the oral cavity. The objectives of this study are to determine the clinicopathologic features in a group of patients with oral leukoplakia of Northern Spain (Galicia), determining the factors associated to clinical risk and analyzing the malignant transformation of these patients. MATERIAL AND
methodsWe included 85 patients. We recorded sex and age, habits like alcohol and tobacco, size, clinical appearance, site, number of lesions, and presence or absence of dysplasia. We assess the association between risk factors and transformation and developed a logistic regression analysis. Finally we used the Kaplan-Meier and log-rank test for the survival analysis.
results7 patients (8.2%) had malignant transformation. The mean follow-up of the patients was 4.13 years versus 5.58 years of those who developed carcinoma. Only location and initial dysplasia have a statistically significant relationship with malignant transformation, but when applied the long rank test only the presence of dysplasia remains statistically significant(P<0,026). Oral Cancer Free Survival was 81.9% (0.150) at 11 years for the group without dysplasia.
conclusionsWe found that the presence of dysplasia is the only risk factor that is statistically related to the development of a carcinoma.
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