Trial reportMedicine and science in sports and exercise2018
Exercise Training Mitigates Multisystem Deconditioning during Bed Rest.
Trial report in Medicine and science in sports and exercise, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Disuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2026Pooled it
- Effects of exercise on bone mineral density and bone turnover markers in adults: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- The role of muscle disuse in muscular and cardiovascular fitness: A systematic review and meta-regression.European journal of sport science · 2024Pooled it
- Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Pooled it
- Limited musculoskeletal benefits of artificial gravity combined with cycling during bed rest: Results from the BRACE study.Experimental physiology · 2026Trial
- Efficacy of Testosterone plus NASA Exercise Countermeasures during Head-Down Bed Rest.Medicine and science in sports and exercise · 2018Trial
- Exercise effects on bed rest-induced brain changes.PloS one · 2018Trial
- Spaceflight and sport science: Physiological monitoring and countermeasures for the astronaut-athlete on Mars exploration missions.Experimental physiology · 2026Review
- Myonuclear and satellite cell content of the vastus lateralis and soleus with 70 days of simulated microgravity and the NASA SPRINT exercise program.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Effects of resistance training on preventing muscle atrophy and bone loss in simulated weightless population: a systematic review and meta-analysis.Frontiers in physiology · 2025Review
- Whole-body vibration transmission during resistance vibration exercise.Frontiers in sports and active living · 2025Article
- Numerical analysis of blood flow in the abdominal aorta under simulated weightlessness and earth conditions.Scientific reports · 2024Article
- Exercise microdosing for skeletal muscle health applications to spaceflight.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Myths and Methodologies: Understanding the health impact of head down bedrest for the benefit of older adults and astronauts. Study protocol of the Canadian Bedrest Study.Experimental physiology · 2024Article
- NASA SPRINT exercise program efficacy for vastus lateralis and soleus skeletal muscle health during 70 days of simulated microgravity.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Effects of body size and countermeasure exercise on estimates of life support resources during all-female crewed exploration missions.Scientific reports · 2023Article
- Human skeletal muscle-specific atrophy with aging: a comprehensive review.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts.NPJ microgravity · 2023Article
- Bone metabolism during strict head-down tilt bed rest and exposure to elevated levels of ambient CONPJ microgravity · 2022Article
- Total Knee Arthroplasty Assessments Should Include Strength and Performance-Based Functional Tests to Complement Range-of-Motion and Patient-Reported Outcome Measures.Physical therapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionThis study investigated the safety and effectiveness of a new integrated aerobic and resistance exercise training prescription (SPRINT) using two different sets of exercise equipment: a suite of large International Space Station-like exercise equipment similar to what is found on the International Space Station and a single device with aerobic and resistance exercise capability in the spaceflight analog of bed rest (BR).
methodsSubjects (n = 34) completed 70 d of 6° head down tilt BR: 9 were randomized to remain sedentary (CONT), 9 to exercise training using traditional equipment (EX), 8 to exercise using traditional equipment and low-dose testosterone supplementation (ExT), and 8 to exercise using a combined resistance and aerobic flywheel device. Peak aerobic capacity, ventilatory threshold, cardiac morphology and function (echocardiography), muscle mass (magnetic resonance imaging) and strength/power (isokinetic, leg press, and vertical jump), and bone health (bone mineral density, blood and urine bone markers) were assessed before and after BR.
resultsThe SPRINT protocol mitigated BR-induced muscle and cardiac deconditioning regardless of the exercise device used. Molecular markers of bone did not change in the CONT or EX groups. Peak aerobic capacity was maintained from pre- to post-BR in all exercise groups similarly, whereas significant declines were observed in the CONT group (~10%). Significant interaction effects between the CONT group and all EX groups were observed for muscle performance including leg press total work, isokinetic upper and lower leg strength, vertical jump power, and maximal jump height as well as muscle size.
conclusionsThis is the first trial to evaluate multisystem deconditioning and the role of an integrated exercise countermeasure. These findings have important implications for the design and implementation of exercise-based countermeasures on future long-duration spaceflight missions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.