Evidence map›Paper›PMID 29924593›Full record

ArticleJournal of the American Chemical Society2018

A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases.

Paola Estrada, Maho Morita, Yue Hao, Eric W Schmidt, Satish K Nair

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Peptide Prenylation Follows Divergent Substrate Engagement Rules.Journal of the American Chemical Society · 2025
    Article
  4. Article
  5. Biosynthesis of guanidine-containing natural products in cyanobacteria.Journal of industrial microbiology & biotechnology · 2024
    Review
  6. Review
  7. Promiscuous Enzymes for Residue-Specific Peptide and Protein Late-Stage Functionalization.Chembiochem : a European journal of chemical biology · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Biochemical characterization of a cyanobactin arginine-Chemical communications (Cambridge, England) · 2022
    Article
  12. Catalysts for the Enzymatic Lipidation of Peptides.Accounts of chemical research · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into anProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  18. Enzymatic studies on aromatic prenyltransferases.Journal of natural medicines · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paola Estrada
Maho MoritaDepartment of Medicinal Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.
Yue Hao
Eric W SchmidtDepartment of Medicinal Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.ORCID 0000-0001-5839-694X

Funding

Structural /Mechanistic Study of Lantibiotic Biosynthetic Enzymes & AutoimmunityR01GM079038 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NAIR, SATISH K · 2006 to 2023
$3.7M
Symbiosis and Chemical Diversity GenerationR35GM122521 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2017 to 2021
$2.9M
Directed posttranslational modifications for drug design and discoveryR01GM102602 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2013 to 2016
$1.4M
NIGMS NIH HHS R01 GM079038NIGMS NIH HHS R01 GM102602NIGMS NIH HHS R35 GM122521
6 · The paper itself

Abstract

Mutation at a single amino acid alters the isoprene donor specificity of prenyltransferases involved in the modification of ribosomally synthesized and post-translationally modified peptides (RiPPs). Though most characterized RiPP prenyltransferases carry out the regiospecific transfer of C

Indexed as

Amino AcidsButadienesDimethylallyltranstransferaseHemiterpenesModels, MolecularMolecular ConformationPeptidesProtein Processing, Post-TranslationalRibosomesAmino AcidsButadienesDimethylallyltranstransferaseHemiterpenesisoprenePeptides

Identifiers

PMID29924593
PMCPMC6467259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.